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作品数：36被引量：100H指数：6
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相关机构：中国医学科学院北京协和医学院徐州医学院附属医院徐州医学院复旦大学更多>>
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Balancing functions of antifouling,nitric oxide release and vascular cell selectivity for enhanced endothelialization of assembled multilayers
《Regenerative Biomaterials》2025年第1期126-141,共16页Sulei Zhang Jun Sun Shuaihang Guo Yichen Wang Yuheng Zhang Jiao Lei Xiaoli Liu Hong Chen 
supported primarily by the National Natural Science Foundation of China(22075191,21774089,and 21935008);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function,Soochow University;the Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application,Soochow University.
Surface endothelialization is a promising way to improve the hemocompatibility of biomaterials.However,current surface endothelialization strategies have limitations.For example,various surface functions are not well ...
关键词：surface modification layer-by-layer self-assembly nitric oxide release heparin analogs ENDOTHELIALIZATION 
Biodegradable Mg alloy modified with bioactive exosomes for cardiovascular stent application
《Journal of Magnesium and Alloys》2024年第12期4988-5004,共17页Ya-chen Hou Jing-an Li Chang Cao Chang Su Zhen Qin Ge Zhang Jia-cheng Guo Jun-nan Tang Jin-ying Zhang Shao-kang Guan 
funded by the Joint Fund of the National Natural Science Foundation of China(U1804251);the Key Scientific and Technological Research Projects in Henan Province(grant number 222102230025);the National Natural Science Foundation of China(Nos.82170281,81870328,and U2004203);the Henan Thousand Talents Program(No.ZYQR201912131);the Excellent Youth Science Foundation of Henan Province(No.202300410362)。
Cardiovascular stent has been widely applied to treat cardiovascular disease(CVD),which is the major disease contribution to mortality in the world wide.Biodegradable magnesium(Mg)alloys are the encouraging materials ...
关键词：Mg-Zn-Y-Nd alloy ENDOTHELIALIZATION Surface modification MgF_(2)-PDA/exosome coating 
Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts
《Bioactive Materials》2024年第11期127-136,共10页Zihao Wang Mengxue Zhou Mengyu Li Jinyu Li Shengmin Zhang Jianglin Wang 
National Key Research and Development Program of China(2022YFA1105100);National Natural Science Foundation of China(32301102;32171323);Fundamental Research Funds for the Central Universities(YCJJ20230215);Science,Technology and Innovation Commission of Shenzhen Municipality(KCXFZ20211020164544008);Sanming Project of Medicine in Shenzhen(SZSM201812055).
Current gold standard for the replacement of small-diameter blood vessel(ID<4 mm)is still to utilize the autologous vessels of patients due to the limitations of small-diameter vascular grafts(SDVG)on weak endothelial...
关键词：Small-diameter vascular grafts Tailored endothelialization Endothelial cell vesicles Click chemistry Vascular remodeling 
Large-Scale Surface Modification of Decellularized Matrix with Erythrocyte Membrane for Promoting In Situ Regeneration of Heart Valve
《Engineering》2024年第10期216-230,共15页Yuqi Liu Pengning Fan Yin Xu Junwei Zhang Li Xu Jinsheng Li Shijie Wang Fei Li Si Chen Jiawei Shi Weihua Qiao Nianguo Dong 
supported by the National Key Research and Development Program of China(2021YFA1101900 and 2023YFB3810100);the National Natural Science Foundation of China(82270381 and 81930052);the Major Science and Technology Special Plan Project of Yunnan Province(202302AA310045).
In situ regeneration is a promising strategy for constructing tissue engineering heart valves(TEHVs).Currently,the decellularized heart valve(DHV)is extensively employed as a TEHV scaffold.Nevertheless,DHV exhibits li...
关键词：In situ tissue engineering heart valves Red blood cell membrane ENDOTHELIALIZATION Hemocompatibility IMMUNOMODULATION 
3D printed grafts with gradient structures for organized vascular regeneration
《International Journal of Extreme Manufacturing》2024年第3期505-520,共16页Yuewei Chen Zhongfei Zou Tao Fu Zhuang Li Zhaojie Zhang Meng Zhu Qing Gao Shaofei Wu Guosheng Fu Yong He Jiayin Fu 
sponsored by the National Natural Science Foundation of China (Nos.52235007, 52325504, T2121004);Zhejiang Province Natural Science Foundation of China under Grant No.LQ23H090012, LQ22H180001;the Science and Technology of Medicine and Health program of Zhejiang Province (No.2023RC028)。
Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great need.However,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis an...
关键词：small-diameter vascular graft smooth muscle layer 3D printing ENDOTHELIALIZATION 
A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve
《Regenerative Biomaterials》2024年第2期123-136,共14页Haoshuang Wu Nuoya Chen Tiantian Zheng Li Li Mengyue Hu Yumei Qin Gaoyang Guo Li Yang Yunbing Wang 
supported by National Key Research and Development Programs(2022YFB3807303 and 2022YFB3807305),National Natural Science Foundation of China(32101107)and CAMS InnovationFundforMedical Sciences(2021-12M-5-013)。
Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over decades.Most clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity...
关键词：bioprosthetic heart valves recombinant humanized collagen typeⅢ ENDOTHELIALIZATION ANTI-CALCIFICATION ANTI-COAGULATION 
Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification被引量：2
《Journal of Materials Science & Technology》2024年第1期250-264,共15页Xiaotong Zhao Jiali Hu Jingjun Nie Dafu Chen Gaowu Qin Erlin Zhang 
supported by the National Key R&D Program of China(No.2022YFB3804400)and(No.2022YFE0122800);Research Program(No.62602010113);Na-tional Natural Science Foundation of China(No.31971253/C1002);Beijing Municipal Health Commission(Nos.BMHC-2021-6,BMHC-2019-9,PXM 2020_026275_000002).
Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical implementation.Given the antibacterial and cardiovas-cular...
关键词：Titanium-copper alloy Titanium-nitride-oxide(TiNxOy) Cu^(2+)release Antibacterial property Cell compatibility 
Bilayer vascular grafts with on-demand NO and H_(2)S release capabilities
《Bioactive Materials》2024年第1期38-52,共15页Pengfei Li Fubang Liang Lijuan Wang Dawei Jin Yushuang Shang Xu Liu Yanjun Pan Jiang Yuan Jian Shen Meng Yin 
supported by the National Natural Science Fund of China(81873923);Jiangsu Higher Education Institutions(19KJA310001 and PAPD);Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.
Nitric oxide(NO)and hydrogen sulfide(H_(2)S)gasotransmitters exhibit potential therapeutic effects in the car-diovascular system.Herein,biomimicking multilayer structures of biological blood vessels,bilayer smalldiame...
关键词：Small-diameter vascular grafts Nitric oxide Hydrogen sulfide KERATIN ENDOTHELIALIZATION 
Degradation and biocompatibility of one-step electrodeposited magnesium thioctic acid/magnesium hydroxide hybrid coatings on ZE21B alloys for cardiovascular stents
《Journal of Magnesium and Alloys》2024年第1期120-138,共19页Zhao-Qi Zhang Bing-Zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang Zheng-Hui Qiu Cun-Guo Lin Rong-Chang Zeng 
the National Key Research and Development Program of China(2018YFC1106703);the National Natural Science Foundation of China(No.U1804251)。
Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based stents.Nevertheless,the steps for preparing comp...
关键词：Magnesium alloy Corrosion resistance Hybrid coating ENDOTHELIALIZATION BIOCOMPATIBILITY 
Functionalization of in vivo tissue-engineered living biotubes enhance patency and endothelization without the requirement of systemic anticoagulant administration被引量：2
《Bioactive Materials》2023年第8期292-305,共14页Hongyu Yan Quhan Cheng Jianghua Si Songdi Wang Ye Wan Xin Kong Ting Wang Wenting Zheng Muhammad Rafique Xiaofeng Li Ju He Adam C.Midgley Yi Zhu Kai Wang 
supported by the National Natural Science Foundation of China(NSFC)projects 81921004(D.K.),82127808(D.K.),32222043(K.W.),82250610231(A.C.M.);National Key R&D Program of China 2022YFA1105102(K.W.);Tianjin Natural Science Foundation 20JCYBJC01150(K.W.);Tianjin Natural Science Foundation 18JCZDJC37600(K.W.);NCC Fund NCC2020PY18(K.W.);Tianjin"Project+Team"Key Training Foundation XC202035(K.W.).
Vascular regeneration and patency maintenance,without anticoagulant administration,represent key developmental trends to enhance small-diameter vascular grafts(SDVG)performance.In vivo engineered autologous biotubes h...
关键词：In vivo tissue-engineering Biotube Living tissue modification ANTICOAGULATION Rapid endothelialization 
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