Degradation and biocompatibility of one-step electrodeposited magnesium thioctic acid/magnesium hydroxide hybrid coatings on ZE21B alloys for cardiovascular stents  

作　　者：Zhao-Qi Zhang Bing-Zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang Zheng-Hui Qiu Cun-Guo Lin Rong-Chang Zeng 

机构地区：[1]School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education),Zhengzhou University,100 Science Road,Zhengzhou 450001,China [2]State Key Laboratory for Marine Corrosion and Protection,Luoyang Ship Material Research Institute,Qingdao 266101,China [3]Corrosion Laboratory for Light Metals,College of Material Science and Engineering,Shandong University of Science and Technology,Qingdao 266590,China

出　　处：《Journal of Magnesium and Alloys》2024年第1期120-138,共19页镁合金学报（英文）

基　　金：the National Key Research and Development Program of China(2018YFC1106703);the National Natural Science Foundation of China(No.U1804251)。

摘　　要：Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based stents.Nevertheless,the steps for preparing composite coatings are usually complicated and time-consuming.Herein,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step electrodeposition.Scanning electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform structure.And the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch test.Electrochemical test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg substrates.Haemocompatibility experiment and cell culture trial detect that the composite coating is of fine biocompatibility.Finally,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and proposed.This coating shows a great potential application for cardiovascular stents.

关 键 词：Magnesium alloy Corrosion resistance Hybrid coating ENDOTHELIALIZATION BIOCOMPATIBILITY 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]