OSTEOCYTES

作品数：23被引量：156H指数：5
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相关领域：医药卫生生物学更多>>
相关机构：西北工业大学更多>>
相关期刊：《Frontiers of Materials Science》《Journal of Cancer Metastasis and Treatment》《Bone Research》《Chinese Journal of Biomedical Engineering(English Edition)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions
《Mechanobiology in Medicine》2024年第2期71-78,共8页Yumei Chen Runze Zhao Li Yang X.Edward Guo 
Bone adapts to mechanical loading by changing its shape and mass.Osteocytes,as major mechanosensors,are critical for bone modeling/remodeling in response to mechanical stimuli.Intracellular calcium oscillation is one ...
关键词：OCY454 OSTEOCYTE MECHANOTRANSDUCTION Fluid flow Extracellular vesicles 
A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis被引量：4
《Bioactive Materials》2023年第3期110-128,共19页Xiaofang Wang Yufei Ma Jie Chen Yujiao Liu Guangliang Liu Pengtao Wang Bo Wang Makoto M.Taketo Teresita Bellido Xiaolin Tu 
National Natural Science Foundation of China U1601220(X.T.),81672118(X.T.),82072450(X.T.),82002310(Y.M.);Chongqing Science and Technology Commission—Basic Science and Frontier Technology Key Project cstc2015jcyjBX0119(X.T.);CQMU Program for Youth Innovation in Future Medicine,W0075(Y.M.).
Cell source is the key to decellularized matrix(DM)strategy.This study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BMSCs)for their ...
关键词：Decellularized matrix OSTEOCYTE Wnt signaling 3D printing Regenerative repair Metabolic and neurovascular organoid bone 
Regulation effect of osteoblasts towards osteocytes by silk fibroin encapsulation
《Frontiers of Materials Science》2022年第4期1-13,共13页Dandan LUO Rui ZHANG Shibo WANG M.Zubair IQBAL Ruibo ZHAO Xiangdong KONG 
supported by the National Natural Science Foundation of China(Grant Nos.51902289 and 51672250);the Natural Science Foundation of Zhejiang Province(Grant No.LQ19E020010);the Project of Zhejiang Provincial Department of Education(Grant No.Y201840323);the Key Project of Zhejiang Science and Technology(Grant Nos.2021C01180 and 2019C04020);the Research Foundation of ZSTU(Grant Nos.18012134-Y and 2020Q008).
Herein,the rational design micromilieus involved silk fibroin(SF)-based materials have been used to encapsulate the osteoblasts,forming an extracellular coated shell on the cells,which exhibited the high potential to ...
关键词：Cell encapsulation silk fibroin osteoblasts modulation cell differentiation cell calcification 
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrinα5被引量：3
《Bone Research》2022年第4期757-769,共13页Dezhi Zhao Rui Hua Manuel A.Riquelme Hongyun Cheng Teja Guda Huiyun Xu Sumin Gu Jean X.Jiang 
supported by the National Institutes of Health(NIH)Grants:AR072020(to J.X.J.);Welch Foundation grant:AQ-1507(to J.X.J.).
Physical mechanical stimulation can maintain and even increase bone mass.Here,we report an important role of osteocytic integrinα5 in regulating the anabolic response of bone to mechanical loading using an Itga5 cond...
关键词：loading ACTIVATION TOGETHER 
Osteocyte pericellular and perilacunar matrices as markers of bone-implant mechanical integrity
《BIOCELL》2022年第10期2209-2216,共8页ReMY GAUTHIER HeLÈNE FOLLET ANA-MARIA TRUNFIO-SFARGHIU DELPHINE FARLAY NINA ATTIK SYLVAIN MEILLE JeRÔME CHEVALIER DAVID MITTON 
To develop durable bone healing strategies through improved control of bone repair,it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants....
关键词：Bone mechanical integrity OSTEOCYTES Pericellular Perilacunar MECHANOSENSITIVITY 
Modified enzymatic collagen digestion-mediated isolation of osteocytes
《BIOCELL》2022年第4期1097-1104,共8页WENJUAN XU GUANGMING DAI YIFEI LYU YINING ZHANG XIAOLIN TU 
supported by the National Natural Science Foundation of China(No.8167090813).
This study established a method for isolating large numbers of high-purity osteocytes from high-density bone.Bone fragments derived from mice tibia and femurs were alternately digested with type I collagenase and EDTA...
关键词：OSTEOCYTES Cell culture Collagen protease SCLEROSTIN Alkaline phosphatase 
PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway被引量：5
《Acta Biochimica et Biophysica Sinica》2021年第12期1640-1649,共10页Yang Liu Mengmeng Duan Daimo Guo Shiyi Kan Li Zhang Munire Aili Demao Zhang Wei Du Jing Xie 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81600840 and 81771047 to J.X.and No.81900965 to W.D.).
Osteocytes are the main sensitive cells in bone remodeling due to their potent functional cell processes from the mineralized bone matrix to the bone surface&the bone marrow.Neighboring osteocytes communicate with eac...
关键词：PDGF-AA cell communication CONNEXIN43 gap junction OSTEOCYTE 
Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone被引量：1
《Bone Research》2021年第4期494-506,共13页Shengzhi Liu Di Wu Xun Sun Yao Fan Rongrong Zha Aydin Jalali Yan Feng Kexin Li Tomohiko Sano Nicole Vike Fangjia Li Joseph Rispoli Akihiro Sudo Jing Liu Alexander Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota 
This study was supported in part by funds from a breast cancer advocacy group,100 Voices of Hope(H.Y.);the Indiana University Precision Health Initiative(H.N.);NIH R01AR52144(H.Y.),R03CA238555(H.Y.),and R01AR053237(A.R.).
Osteocytes are the most abundant cells in bone,which is a frequent site of breast cancer metastasis.Here,we focused on Wnt signaling and evaluated tumor-osteocyte interactions.In animal experiments,mammary tumor cells...
关键词：cytes ELEVATED inhibited 
In silico analysis of RNA and small RNA sequencing data from human BM-MSCs and differentiated osteocytes, chondrocytes and tenocytes
《Engineered Regeneration》2021年第1期19-30,共12页Srinivas V.Koduru Irina A.Elcheva Ashley N.Leberfinger Dino J.Ravnic 
Background:Adult stem cells have a remarkable capacity of differentiating into various cell types necessary for tissue and organ regeneration.Multiple studies have focused on the differentiation potential of mesenchym...
关键词：BM-MSCs OSTEOCYTES CHONDROCYTES TENOCYTES Small RNA miRNA-mRNA 
The multifunctional role of Notch signaling in multiple myeloma
《Journal of Cancer Metastasis and Treatment》2021年第1期300-314,共15页Hayley MSabol Jesus Delgado-Calle 
supported by the National Institutes of Health(R37-CA251763 to J.D.C.);the Arkansas COBRE program(NIGMS P20GM125503)to J.D.C.,a Scholar Award by the American Society of Hematology Scholar Award(to J.D.C);a Brian D.Novis Award by the International Myeloma Foundation(to J.D.C.).
Multiple myeloma(MM)is a hematologic cancer characterized by uncontrolled growth of malignant plasma cells in the bone marrow and currently is incurable.The bone marrow microenvironment plays a critical role in MM.MM ...
关键词：NOTCH tumor microenvironment multiple myeloma bone OSTEOCYTES OSTEOCLASTS OSTEOBLASTS γ-secretase inhibitors 
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