The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism  

作　　者：Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong 

机构地区：[1]College of Bioengineering,Chongqing University,Chongqing 400044,China [2]Department of Biomedical Materials Science,College of Biomedical Engineering,Army Medical University(Third Military Medical University),Chongqing 400038,China [3]State Key Laboratory of Trauma and Chemical Poisoning,Army Medical University(Third Military Medical University),Chongqing 400038,China

出　　处：《Genes & Diseases》2024年第4期220-233,共14页基因与疾病（英文）

基　　金：sponsored by the Key Program of the National Natural Science Foundation of China(No.81930067);the Natural Science Foundation of China(No.82002316);the Youth Cultivation Project of Army Medical University(China)(No.2020XQN08).

摘　　要：In recent years,researchers have become focused on the relationship between lipids and bone metabolism balance.Moreover,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic phenotypes.It has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone mass.Furthermore,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal models.Abnormal lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards osteoblasts.Moreover,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of osteoclasts.Conclusively,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism bal-ance.We also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关 键 词：Bone homeostasis Cross-organ communication Lipid metabolism OSTEOCLAST OSTEOPOROSIS 

分 类 号：R681[医药卫生—骨科学]