circFKBP8(5S,6)-encoded protein as a novel endogenous regulator in major depressive disorder by inhibiting glucocorticoid receptor nucleus translocation  

环状RNAcircFKBP8(5S,6)编码蛋白质作为一种新的内源性调节因子影响糖皮质激素受体核转位参与抑郁障碍的发病机制

作　　者：Jiao Jiao Dandan Xu Yan Kong Yujia Cao Liyuan Wang Yuan Hong Ling Li Chenyu Gao Jing Liu Gaojia Zhang Jiangning Zhou Ji Dai Zhonghua Lu Yan Liu Yutian Wang Zhijun Zhang 焦娇;徐丹丹;孔岩;曹育嘉;王俐媛;洪源;李玲;高晨雨;刘婧;张高嘉;周江宁;戴辑;路中华;刘妍;王玉田;张志珺

机构地区：[1]Department of Neurology,Affiliated Zhongda Hospital,Research Institution of Neuropsychiatry,School of Medicine,Key Laboratory of Developmental Genes and Human Disease,Southeast University,Nanjing 210009,China [2]Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression,Department of Mental Health and Public Health,Faculty of Life and Health Sciences,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]Department of Biochemistry and Molecular Biology,School of Medicine,Southeast University,Nanjing 210009,China [4]Institute for Stem Cell and Neural Regeneration,State Key Laboratory of Reproductive Medicine,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China [5]Department of Anesthesiology,Shenzhen Maternity&Child Healthcare Hospital,The First School of Clinical Medicine,Southern Medical University,Shenzhen 518027,China [6]Shenzhen Key Laboratory for Molecular Biology of Neural Development,The Brain Cognition and Brain Disease Institute,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [7]CAS Key Laboratory of Brain Function and Diseases,Life Science School,University of Science and Technology of China,Hefei 230026,China [8]Shenzhen-Hong Kong Institute of Brain Science,Shenzhen 518055,China [9]Faculty of Life and Health Sciences,Shenzhen Institutite of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [10]Department of Medicine and DM Center for Brain Health,University of British Columbia,Vancouver V6T 1Z4,Canada

出　　处：《Science Bulletin》2024年第24期3826-3831,共6页科学通报(英文版)

基　　金：supported by the Chinese Science and Technology Innovation 2030-Major Project(2022ZD0211701 and 2021ZD0200700);the National Natural Science Foundation of China(82130042,81830040 and 82371532);Shenzhen Science and Technology Serial Funds(GJHZ20210705141400002,KCXFZ20211020164543006,JCYJ20220818101615033,ZDSYS202-20606100606014,and KQTD20221101093608028).

摘　　要：Major depressive disorder(MDD)is a debilitating mental health condition that ranks second in the global burden of human diseases[1].Despite extensive research,the etiology and pathogenesis of MDD remain poorly understood.Disturbance of the hypothalamic-pituitary-adrenal(HPA)axis mediated by glucocorticoid receptor(GR)dysfunction has been recognized to be associated with the occurrence of MDD[2].

关 键 词：GLUCOCORTICOID ENDOGENOUS INHIBITING 

分 类 号：R749.4[医药卫生—神经病学与精神病学]