Vagus nerve stimulation in cerebral stroke:biological mechanisms,therapeutic modalities,clinical applications,and future directions  

作　　者：Li Du Xuan He Xiaoxing Xiong Xu Zhang Zhihong Jian Zhenxing Yang 

机构地区：[1]Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China [2]Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China

出　　处：《Neural Regeneration Research》2024年第8期1707-1717,共11页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Hubei Province,No.2022CBF680;Independent Scientific Research Project of Wuhan University,No.2042022kf1119(both to LD)。

摘　　要：Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of life.Many stro ke victims are left with long-term neurological dysfunction,which adversely affects the well-being of the individual and the broader socioeconomic impact.Currently,poststroke brain dysfunction is a major and difficult area of treatment.Vagus nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autis m,refractory depression,epilepsy,and Alzheimer’s disease.It is expected to be a novel therapeutic technique for the treatment of stroke owing to its association with multiple mechanisms such as alte ring neurotransmitters and the plasticity of central neuro ns.In animal models of acute ischemic stroke,vagus nerve stimulation has been shown to reduce infarct size,reduce post-stroke neurological damage,and improve learning and memory capacity in rats with stroke by reducing the inflammatory response,regulating bloodbrain barrier permeability,and promoting angiogenesis and neurogenesis.At present,vagus nerve stimulation includes both invasive and non-invasive vagus nerve stimulation.Clinical studies have found that invasive vagus nerve stimulation combined with rehabilitation therapy is effective in im proving upper limb motor and cognitive abilities in stroke patients.Further clinical studies have shown that non-invasive vagus nerve stimulation,including ear/ce rvical vagus nerve stimulation,can stimulate vagal projections to the central nervous system similarly to invasive vagus nerve stimulation and can have the same effect.In this paper,we first describe the multiple effects of vagus nerve stimulation in stroke,and then discuss in depth its neuroprotective mechanisms in ischemic stroke.We go on to outline the res ults of the current major clinical applications of invasive and non-invasive vagus nerve stimulation.Finally,we provide a more comprehensive evaluation of the advantages and disadvantages of different types of vagus nerve stimulation in th

关 键 词：cerebral stroke NEUROPLASTICITY non-invasive vagus nerve stimulation REHABILITATION vagus nerve stimulation 

分 类 号：R743.3[医药卫生—神经病学与精神病学]