supported by the National Natural Science Foundation of China,Nos.82271327 (to ZW),82072535 (to ZW),81873768 (to ZW),and 82001253 (to TL)。
The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and ce...
supported by the National Natural Science Foundation of China(32072126 and 32230075);the Shandong Provincial Natural Science Foundation(ZR2019MC005).
Pentatricopeptide repeat(PPR)proteins are a large group of eukaryote-specific RNA-binding proteins that play pivotal roles in plant organelle gene expression.Here,we report the function of PPR21 in mitochondrial intro...
supported by the National Natural Science Foundation of China (No. 30872716);the Natural Science Foundation of Hubei Province,China (No. 2015CFB288);Open Foundation of Hubei Province Key Laboratory of Tumor Microenvironment and immunotherapy (No. 2023KZL06)。
Mitochondria play an important role in pressure overload-induced cardiac hypertrophy.The present study aimed to investigate the role of mitochondrial transient receptor potential vanilloid 3(TRPV3)in myocardial hypert...
Supported by Instituto de Ciencia,Tecnología e Innovación-Gobierno del Estado de Michoacán,México,No.ICTI-PICIR23-063;Programa Proyectos de Investigación Financiados 2024,Coordinación de Investigación Científica,Universidad Michoacana de San Nicolás de Hidalgo,México.
In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin secretion.Despite numerous in vitro and pre-clinical studies supporting the invol...
supported by the National Key Research and Development Program of China (Nos. 2019YFA0802-702-1, 2022YFC2705100, 2022YFC2705105);the National Natural Science Foundation of China (Nos. 82070701, 82090022, and 8183-0020);the Natural Science Foundation of Jiangsu Province (No. BK20231130);the Social Development Foundation of Jiangsu Province(No. BE2021607);the “333” Talent Plan of Jiangsu Province (No.333-2022001);the Medical Research Project from Jiangsu Health and Health Commission (No. Z2022071);the Outstanding Youth Project from Nanjing Health and Health Commission (No.JQX22010)。
Pharmaceutical formulations derived from Aristolochiaceae herbs, which contain aristolochic acids(AAs), are widely used for medicinal purposes. However, exposure to these plants and isolated AAs is linked to renal tox...
This paper presents a comprehensive overview of the historical trajectory and development in biophoton studies over the past 100 years,with a particular focus on the recent progress regarding the pivotal role of bioph...
This work was supported by the National Natural Science Foundation of China(31902161);the National Key Research and Development Program of China(2022YFD1302201,2018YFA0107001);Strategic Priority Research Program of Chinese Academy of Sciences(XDA24020203);Key Research and Development Program of Hubei Province(2021BBA221);Major Project of Hubei Hongshan Laboratory(2021hszd003);Foundation of Key Laboratory of Animal Genetics,Breeding and Reproduction in the Plateau Mountainous Region,Ministry of Education,Guizhou University(QJHKY[2022]373).
Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early embryos.Current studies have illustrated several pioneer factors as being important for agricultural animals,but wh...
the National Natural Science Foundation of China(31971893,U2004144);the Key Technologies R&D Program of Henan Province(232102111080,212102110043);Academician Expert Workstation(202305AF150082).
Mitochondrial protein translation that is essential for aerobic energy production includes four essential steps of the mitochondrial ribosome cycle,namely,initiation,elongation,termination of the polypeptide,and ribos...
The Triticum-Aegilops complex provides ideal models for the study of polyploidization,and mitochondrial genomes(mtDNA)can be used to trace cytoplasmic inheritance and energy production following polyploidization.In th...
This work was supported by the NationalNatural Science Foundation of China(grant nos.221930301,21961142022,22072160,and 21872150);.J.F.particularly thanks to Institute of Chemistry,CAS(grant no.Y6290512B1).
Herein,we couple a synthetic electrozyme in a supramolecule-assembled nanoarchitecture to achieve enhanced bioenergy transformation by mimicking mitochondrial oxidative phosphorylation.Different from the natural count...