Enhanced Bioenergy Transformation by Metal-Free Electrozyme-Based Mitochondrion Nanoarchitectonics  

作　　者：Tonghui Wang Jinbo Fei Zhenzhen Dong Xia Xu Weiguang Dong Junbai Li 

机构地区：[1]Beijing National Laboratory for Molecular Sciences(BNLMS),CAS Key Lab of Colloid,Interface and Chemical Thermodynamics,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190 [2]University of Chinese Academy of Sciences,Beijing 100049

出　　处：《CCS Chemistry》2023年第7期1644-1652,共9页中国化学会会刊（英文）

基　　金：This work was supported by the NationalNatural Science Foundation of China(grant nos.221930301,21961142022,22072160,and 21872150);.J.F.particularly thanks to Institute of Chemistry,CAS(grant no.Y6290512B1).

摘　　要：Herein,we couple a synthetic electrozyme in a supramolecule-assembled nanoarchitecture to achieve enhanced bioenergy transformation by mimicking mitochondrial oxidative phosphorylation.Different from the natural counterpart,the metal-free electrozyme is a semiconducting polymer deposited on an electrode.The wellmatched electrocatalytic property of the electrozyme permits oxidization of reduced nicotinamide adenine dinucleotide(NADH)to release protons under a much lower electric potential.As a consequence,the generated proton gradient drives rotary catalysis of adenosine 5′-triphosphate(ATP)synthase reconstituted in a lipid membrane to produce ATP.Remarkably,electrochemical bioenergy conversion of NADH to ATP is accomplished with much higher efficiency in such a bio-like system compared with the natural mitochondria.This work integrates synthetic and natural catalytic chemistry to facilitate enhanced bioenergy transformation,thereby greatly improving prospects in ATP-fueled bioapplications.

关 键 词：molecular assembly BIOENERGY nanozyme BIOCATALYSIS nanoarchitectonics 

分 类 号：O64[理学—物理化学]