Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment  

作　　者：Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu 

机构地区：[1]Department of Clinical Laboratory,Beijing Bo’ai Hospital,China Rehabilitation Research Center,Capital Medical University,Beijing,China [2]Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Beijing Advanced Innovation Center for Big Data-based Precision Medicine,Capital Medical University,Beijing,China [3]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,China

出　　处：《Neural Regeneration Research》2025年第9期2598-2610,共13页中国神经再生研究（英文版）

基　　金：supported by the Scientific Research Project of China Rehabilitation Research Center,No.2021zx-23;the National Natural Science Foundation of China,No.32100925;the Beijing Nova Program,No.Z211100002121038。

摘　　要：Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive impairment.We found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic stroke.In addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic stroke.Serum phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic stroke.Furthermore,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein levels.Although ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein levels.Taken together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关 键 词：BIOMARKER high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment 

分 类 号：R743.3[医药卫生—神经病学与精神病学]