ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease  

作　　者：Jasmin Galper Nicolas Dzamko Woojin Scott Kim 

机构地区：[1]Brain and Mind Center&School of Medical Sciences,Faculty of Medicine and Health,The University of Sydney,Sydney,NSW,Australia

出　　处：《Neural Regeneration Research》2026年第2期669-670,共2页中国神经再生研究(英文版)

摘　　要：A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative diseases such as PD and Alzheimer’s disease(AD)and is thought to reflect lysosome dysfunction,lipid accumulation may also contribute to and be indicative of severe lysosomal dysfunction.Much is known about the detrimental effects of glucosylceramide accumulation in PD lysosomes.

关 键 词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease 

分 类 号：R742.5[医药卫生—神经病学与精神病学]