Targeting lysosomes in human disease:from basic research to clinical applications  

作　　者：Mengdie Cao Xiangyuan Luo Kongming Wu Xingxing He 

机构地区：[1]Institute of Liver and Gastrointestinal Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China [2]Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China [3]Department of Medical Oncology,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,450008 Zhengzhou,China [4]Department of Oncology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第12期3393-3420,共28页信号转导与靶向治疗（英文）

基　　金：This research was financially supported by the National Natural Science Foundation of China(No.82073095).

摘　　要：In recent years,accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis.Lysosomal changes and dysfunction have been correlated with the development of numerous diseases.In this review,we interpreted the key biological functions of lysosomes in four areas:cellular metabolism,cell proliferation and differentiation,immunity,and cell death.More importantly,we actively sought to determine the characteristic changes and dysfunction of lysosomes in cells affected by these diseases,the causes of these changes and dysfunction,and their significance to the development and treatment of human disease.Furthermore,we outlined currently available targeting strategies:(1)targeting lysosomal acidification;(2)targeting lysosomal cathepsins;(3)targeting lysosomal membrane permeability and integrity;(4)targeting lysosomal calcium signaling;(5)targeting mTOR signaling;and(6)emerging potential targeting strategies.Moreover,we systematically summarized the corresponding drugs and their application in clinical trials.By integrating basic research with clinical findings,we discussed the current opportunities and challenges of targeting lysosomes in human disease.

关 键 词：CLINICAL METABOLISM IMMUNITY 

分 类 号：R91[医药卫生—药学]