RETROMER

作品数：19被引量：43H指数：4
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相关领域：生物学更多>>
相关作者：宋砚泽苏立波林鑫华李雪吴一卉更多>>
相关机构：福建农林大学中国科学院大学温州医科大学中国科学院更多>>
相关期刊：《Cell Regeneration》《中国科学：生命科学》《Frontiers in Biology》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目福建省自然科学基金更多>>
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SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation
《Acta Pharmacologica Sinica》2025年第4期964-975,共12页Hong Li Ming-xia Peng Rui-xue Yang Jian-xing Chen Yue-mei Wang Pan-xia Wang Yue-huai Hu Di-yi Pan Pei-qing Liu Jing Lu 
supported by the National Natural Science Foundation of China(82473914,82173808,U21A20419,81903606);Guangzhou Basic and Applied Basic Research Project(2024A04J10013,202102021272);Guangdong Provincial Key Laboratory of Construction Foundation(2017B030314030);Traditional Chinese Medicine Bureau of Guangdong Province(20231134,20231158).
Sorting nexins(SNXs)as the key regulators of sorting cargo proteins are involved in diverse diseases.SNXs can form the specific reverse vesicle transport complex(SNXs-retromer)with vacuolar protein sortings(VPSs)to so...
关键词：heart failure cardiac hypertrophy SNX3 HMGB1 RETROMER ISOPROTERENOL 
The plant retromer components SNXs bind to ATG8 and CLASP to mediate autophagosome movement along microtubules
《Molecular Plant》2025年第3期416-436,共21页Yanglan Liao Xibao Li Wenlong Ma Xinyi Lin Jiayi Kuang Xuanang Zheng Zien Li Fanfan Qiao Chuanliang Liu Jun Zhou Faqiang Li Ruixi Li Byung-Ho Kang Hongbo Li Caiji Gao 
supported by grants from the National Natural Science Foundation of China(32270291,32061160467,32470797,and 31870171);the Guangdong Province Rural Revitalization Strategy Special Funding for Seed Industry Vitalization to C.G.,the NSFC grant(32000365,32370329);Guangdong Basic and Applied Basic Research Foundation(2021A1515010913,2024B1515020043);H.L.,and the Research Grant Council of Hong Kong(GRF14113921,GRF14109222,GRF14110823,N_CUHK462/22,and C4014-23G)to B.-H.K.
In eukaryotic cells,autophagosomes are double-membrane vesicles that are highly mobile and traffic along cytoskeletal tracks.While core autophagy-related proteins(ATGs)and other regulators involved in autophagosome bi...
关键词：autophagy SNX CLASP MICROTUBULE autophagosome trafficking Arabidopsis thaliana 
Structural determinants specific for retromer protein sorting nexin 5 in regulating subcellular retrograde membrane trafficking
《The Journal of Biomedical Research》2023年第6期492-506,共15页Qing Chen Meiheng Sun Xu Han Hongfei Xu Yongjian Liu 
This work was supported by the National Natural Science Foundation of China(Grant Nos.31371436 and 8157051134 to Y.L.);by the laboratory start-up grant from Nanjing Medical University(to Y.L.).
The endosomal trafficking of signaling membrane proteins, such as receptors, transporters and channels, is mediated by the retromer-mediated sorting machinery, composed of a cargo-selective vacuolar protein sorting tr...
关键词：vesicular monoamine transporter 2 SNX5 SNX6 RETROMER retrograde trafficking 
GTPase-activating protein TBC1D5 coordinates with retromer to constrain synaptic growth by inhibiting BMP signaling被引量：1
《Journal of Genetics and Genomics》2023年第3期163-177,共15页Xiu Zhou Guangming Gan Yichen Sun Mengzhu Ou Junhua Geng Jing Wang Xi Yang Shu Huang Da Jia Wei Xie Haihuai He 
supported by research grants from the National Natural Science Foundation of China(31671510 and 31871461 to H.H.;31771592 to W.X.)。
Formation and plasticity of neural circuits rely on precise regulation of synaptic growth.At Drosophila neuromuscular junction(NMJ),Bone Morphogenetic Protein(BMP)signaling is critical for many aspects of synapse form...
关键词：TBC1D5 NMJ Synaptic growth RETROMER BMP signaling 
The emerging roles of retromer and sorting nexins in the life cycle of viruses
《Virologica Sinica》2022年第3期321-330,共10页Yue Lu Ping He Yuxuan Zhang Yongwen Ren Leiliang Zhang 
supported by grants from National Natural Science Foundation of China(81871663 and 82072270);Undergraduate Science and Technology Innovation Plan of International Class of Clinical Medicine in Shandong First Medical University(ZYKC2019-016);Academic promotion programme of Shandong First Medical University(2019LJ001)。
Retromer and sorting nexins(SNXs)transport cargoes from endosomes to the trans-Golgi network or plasma membrane.Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses,includ...
关键词：RETROMER CORONAVIRIDAE FLAVIVIRIDAE RETROVIRIDAE Sorting nexin(SNX) 
Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway被引量：4
《Genes & Diseases》2021年第2期232-240,共9页Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang 
This work was supported by National Natural Science Foundation of China(grant numbers 81872270 and 81572683 to NT),the Natural Science Foundation Project of Chongqing(cstc2019jcyj-msxmX0587 to KW),the Science and Technology Research Program of Chongqing Municipal Education Commission(Grant number KJQN201900429 to KW),the Major National S&T program(2017ZX10202203-004 to NT),Natural Science Foundation Project of CQ CSTC(cstc2018jcyjAX0254 to NT),and the Leading Talent Program of CQ CSTC(CSTCCXLJRC201719 to NT).
Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms...
关键词：Epithelial emesenchymal transition Hepatocellular carcinoma(HCC) METASTASIS Retromer complex VPS35 Wnt/PCP signaling pathway 
FgRab5 and FgRab7 are essential for endosomes biogenesis and nonredundantly recruit the retromer complex to the endosomes in Fusarium graminearum被引量：1
《Stress Biology》2021年第1期203-214,共12页Yakubu Saddeeq Abubakar Han Qiu Wenqin Fang Huawei Zheng Guodong Lu Jie Zhou Zonghua Wang Wenhui Zheng 
supported by grants from the National Natural Science Foundation of China(31772106)and the Natural Science Foundation of Fujian Province(2021J06015).The funders had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
The retromer complex,composed of the cargo-selective complex(CSC)Vps35-Vps29-Vps26 in complex with the sorting nexin dimer Vps5-Vps17,mediates the sorting and retrograde transport of cargo proteins from the endosomes ...
关键词：Fusarium graminearum Rab GTPases RETROMER vesicle trafficking 
All ways lead to Rome: assembly of retromer on membranes with different sorting nexins被引量：1
《Signal Transduction and Targeted Therapy》2021年第4期1088-1089,共2页Xin Yong Daniel D.Billadeau Da Jia 
Research in the authors laboratory is supported by Natural Science Foundation of China(NSFC)grants(#91854121,#31871429);National Key Research and Development Program of China(2018YFC1005004);Sichuan Science and Technology Program(2018RZ0128);US NIH grant(DK107733 to D.D.B.).
In a recent paper published in Science Advances,Leneva et al.1 present cryo-electron tomography structures of assembling metazoan and fungal core retromer complexes(VPS29/VPS35/VPS26)on membranes enriched in Фx(L/M/V...
关键词：CURVATURE COMPLEXES RESIDUE 
Taking out the garbage:cathepsin D and calcineurin in neurodegeneration被引量：5
《Neural Regeneration Research》2017年第11期1776-1779,共4页Andreas Aufschnaiter Verena Kohler Sabrina Büttner 
supported by the Austrian Science Fund FWF(No.P27183-B24);the Swedish Research Council Vetenskapsradet(No.2015-05468);Ake Wiberg Stiftelse(No.M16-0130);Carl Trygger Stiftlese(No.CTS16:85);Goljes Stiftelse(No.LA2016-0123)
Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to ma...
关键词：NEURODEGENERATION Parkinson’s disease Α-SYNUCLEIN cathepsin D CALCINEURIN RETROMER yeast LYSOSOME endosomal sorting 
Retromer localizes to autophagosomes during HCV replication被引量：1
《Virologica Sinica》2017年第3期245-248,共4页Peiqi Yin Zhi Hong Leiliang Zhang Youyang Ke 
supported by grants from the National Natural Science Foundation of China(81471955,81672035,81301438);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-3-020);the National Key Plan for Research and Development of China(2016YFD0500300);the Program for Changjiang Scholars and Innovative Research Team in University(IRT13007);the Fundamental Research Funds for the Central Universities,the PUMC Youth Fund(3332016085)
Dear Editor,Hepatitis C virus（HCV）is a positive-strand RNA virus that belongs to the genus Hepacivirus within the Flaviviridae family.HCV causes chronic liver diseases,and185 million people are infected（Messina et ...
关键词：Flaviviridae replication belongs approved autophagy vaccine infected strand RNA cargo 
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