ISOPROTERENOL

作品数：78被引量：229H指数：8
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相关机构：军事医学科学院哈尔滨医科大学邯郸市第一医院北京大学更多>>
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SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation
《Acta Pharmacologica Sinica》2025年第4期964-975,共12页Hong Li Ming-xia Peng Rui-xue Yang Jian-xing Chen Yue-mei Wang Pan-xia Wang Yue-huai Hu Di-yi Pan Pei-qing Liu Jing Lu 
supported by the National Natural Science Foundation of China(82473914,82173808,U21A20419,81903606);Guangzhou Basic and Applied Basic Research Project(2024A04J10013,202102021272);Guangdong Provincial Key Laboratory of Construction Foundation(2017B030314030);Traditional Chinese Medicine Bureau of Guangdong Province(20231134,20231158).
Sorting nexins(SNXs)as the key regulators of sorting cargo proteins are involved in diverse diseases.SNXs can form the specific reverse vesicle transport complex(SNXs-retromer)with vacuolar protein sortings(VPSs)to so...
关键词：heart failure cardiac hypertrophy SNX3 HMGB1 RETROMER ISOPROTERENOL 
Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals
《Animal Models and Experimental Medicine》2025年第1期67-91,共25页Lujain Bader Eddin Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Samer NGoyal Shreesh Ojha 
United Arab Emirates University,Grant/Award Number:12R104 and 12R121。
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extra...
关键词：cardiac fibrosis CATECHOLAMINES experimental models ISOPROTERENOL myocardial fibrosis PHYTOCHEMICALS β-adrenergic receptors 
Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats:Implications on oxidative balance,autophagy,and apoptosis
《Sports Medicine and Health Science》2024年第4期344-357,共14页Hakimeh Shahsavarnajand Bonab Javad Tolouei Azar Hamid Soraya Akbar Nouri Habashi 
This study aimed to investigate the potential cardioprotective effects of moderate and high-intensity aerobic interval training(MIIT and HIIT)preconditioning.The focus was on histological changes,pro-oxidant-antioxida...
关键词：Pathological cardiac remodeling Aerobic interval training preconditioning Oxidative stress AUTOPHAGY APOPTOSIS 
In vivo proximity proteomics uncovers palmdelphin(PALMD)as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury
《Acta Pharmacologica Sinica》2024年第12期2540-2552,共13页Cong-ting Guo Blake DJardin Jun-sen Lin Rachelle LAmbroise Ze Wang Lu-zi Yang Neil Mazumdar Fu-jian Lu Qing Ma Yang-po Cao Can-zhao Liu Kai-long Li Xu-jie Liu Feng Lan Ming-ming Zhao Han Xiao Er-dan Dong William T.Pu Yu-xuan Guo 
funded by the National Key R&D Program of China(2022YFA1104800);the National Natural Science Foundation of China(82222006);the Beijing Nova Program(20220484205)and Beijing Natural Science Foundation(7232094);supported by National Institute of Health(R01HL146634 and R01HL163937);supported by the Natural Science Foundation of China(82070235 and 92168113);the CAMs Innovation Fund for Medical Sciences(2021-12M-5-003);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0047);supported by the National Natural Science Foundation of China(82170231);Guangdong Basic and Applied Basic Research Foundation(2023B1515020103).
Z-discs are core ultrastructural organizers of cardiomyocytes that modulate many facets of cardiac pathogenesis.Yet a comprehensive proteomic atlas of Z-disc-associated components remain incomplete.Here,we established...
关键词：proximity proteomics sarcomere Z-disc isoproterenol induced cardiac injury palmdelphin 
Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model
《World Journal of Traditional Chinese Medicine》2024年第4期443-450,共8页Arul Mozhi Padmanabhan Victor Arokia Doss 
Objective:This study aimed to validate the synergistic effects of Cinnamomum verum(C.verum) barks and stingless bee honey(SBH)against cardiac hypertrophy(CH).Materials and Methods:Isoproterenol(ISO-group Ⅱ-30 mg/kg)-...
关键词：Cardiac hypertrophy Cinnamomum verum ISOPROTERENOL METABOLISM stingless bee honey 
Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats
《Asian Pacific Journal of Tropical Biomedicine》2024年第6期236-244,共9页Hital Shah Tejal Gandhi 
Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in rats.Methods:Wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betul...
关键词：NF-ΚB ISOPROTERENOL BETULIN Myocardial injury Oxidative stress INFLAMMATION Apoptosis 
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy:Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits
《Current Medical Science》2024年第2期450-461,共12页Xiao-yun DING Hao ZHANG Yu-mei QIU Meng-die XIE Hu WANG Zheng-yu XIONG Ting-ting LI Chun-ni HE Wei DONG Xi-lan TANG 
supported by grants from the National Natural Science Foundation of China(Nos.81960732 and 82060733);the Natural Science Foundation of Jiangxi Province(No.20224BAB206111);the Science and Technology Plan of Jiangxi Provincial Health Commission(No.202311141);the Open Project of Jiangxi Provincial Key Laboratory of Drug Design and Evaluation(No.JKLDE-KF-2101);the Open Project of Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine(No.TCM-201911).
Objective:Cymbopogon citratus(DC.)Stapf is a medicinal and edible herb that is widely used for the treatment of gastric,nervous and hypertensive disorders.In this study,we investigated the cardioprotective effects and...
关键词：Cymbopogon citratus essential oil cardiac hypertrophy NLRP3 inflammasome oxidative phosphorylation complex subunits 
Isoproterenol induces MD2 activation by β-AR-cAMP-PKA-ROS signalling axis in cardiomyocytes and macrophages drives inflammatory heart failure被引量：2
《Acta Pharmacologica Sinica》2024年第3期531-544,共14页Jin-fu Qian Shi-qi Liang Qin-yan Wang Jia-chen Xu Wu Luo Wei-jian Huang Gao-jun Wu Guang Liang 
supported by the National Natural Science Foundation of China(82271347 to GJW);Wenzhou City Research Project(ZY2020016 to GJW).
Cardiac inflammation contributes to heart failure(HF)induced by isoproterenol(ISO)through activatingβ-adrenergic receptors(β-AR).Recent evidence shows that myeloid differentiation factor 2(MD2),a key protein in endo...
关键词：heart failure ISOPROTERENOL inflammation MD2 CARDIOMYOCYTES MACROPHAGES 
A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats
《Chinese Medicine》2023年第4期242-254,共13页Zumeng Xia Hoi Yan Leung Hoi Ling Siu Chung Wai Chan Kam Ming Ko 
The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg ...
关键词：Cardiomyopeptin Herbal Extract Chronic Heart Failure ISOPROTERENOL 
Naringenin suppresses NLRP3 inflammasome activation via the mRNA-208a signaling pathway in isoproterenol-induced myocardial infarction
《Asian Pacific Journal of Tropical Biomedicine》2023年第10期443-450,共8页Ayman Eldourghamy Toka Hossam Mohammed Abdalla Hussein Amal Abdel-Aziz Samir A.El-masry 
Objective:To investigate the cardioprotective effect of naringenin against isoproterenol(ISO)-induced cardiotoxicity in rats.Methods:Rats were divided into five groups:the normal group,the ISO group(85 mg/kg b.w.);the...
关键词：NARINGENIN ISOPROTERENOL Myocardial infarction Antioxidants NLRP3 mRNA-208a 
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