Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol-induced Cardiac Hypertrophic Murine Model  

作　　者：Arul Mozhi Padmanabhan Victor Arokia Doss 

机构地区：[1]Department of Biochemistry,PSG College of Arts and Science,Coimbatore,Tamil Nadu,India

出　　处：《World Journal of Traditional Chinese Medicine》2024年第4期443-450,共8页世界中医药杂志(英文)

摘　　要：Objective:This study aimed to validate the synergistic effects of Cinnamomum verum(C.verum) barks and stingless bee honey(SBH)against cardiac hypertrophy(CH).Materials and Methods:Isoproterenol(ISO-group Ⅱ-30 mg/kg)-induced cardiac hypertrophic Wistar rats were used in this study.Hypertrophic rats were treated using the reference drug losartan(LOS Group Ⅲ:50 mg/kg) and aqueous extracts of C.verum barks and SBH(ACH Group Ⅳ:250 mg/kg and 250 mg/kg).CH was characterized by electrocardiography,hypertrophic indices,and biochemical estimations such as total glucose,protein,albumin,lipid profiles,cardiac marker enzymes,and histopathological studies.Results:Rats received ISO had increased levels of glucose,protein,cholesterol,triglycerides,very low-density lipoprotein,and low-density lipoprotein,coupled with decreased levels of albumin and high-density lipoprotein.These levels were restored to near normal when treated with ACH extracts of the standard drugs.Contrary to the ISO-induced myocardial damaged hearts,ACH extracts had a profound effect compared to LOS,which was also reflected in histopathological studies.Conclusion:These data explicitly reveal that the ACH have a synergistic cardioprotective(antihypertrophic) effect.

关 键 词：Cardiac hypertrophy Cinnamomum verum ISOPROTERENOL METABOLISM stingless bee honey 

分 类 号：R285.5[医药卫生—中药学]