BETULIN

作品数：18被引量：27H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：张玉红于涛王洋更多>>
相关机构：东北林业大学更多>>
相关期刊：《Medicinal Plant》《Acta Pharmacologica Sinica》《Journal of Pharmacy and Pharmacology》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金河北省自然科学基金更多>>
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Haplotype-resolved genome of a heterozygous wild peach reveals the PdaWRKY4-PdaCYP716A1 module mediates resistance to aphids by regulating betulin biosynthesis
《Journal of Integrative Plant Biology》2024年第12期2716-2735,共20页Jun-Xiu Wang Yong Li Xin-Wei Wang Ke Cao Chang-Wen Chen Jin-Long Wu Wei-Chao Fang Geng-Rui Zhu Xue-Jia Chen Dan-Dan Guo Jiao Wang Ya-Lin Zhao Jia-Qi Fan Su-Ning Liu Wen-Qing Li Hang-Ling Bie Qiang Xu Li-Rong Wang 
supported by the National Key Research and Development Program(2023YFE0105400);Central Public-interest Scientific Institution Basal Research Fund(Y2022QC23);the Agricultural Science and Technology Innovation Program(CAAS-ASTIP-2023-ZFRI-01);Natural Science Foundation of Henan(232300421042);the Crop Germplasm Resources Conservation Project(2016NWB041);the National Natural Science Foundation of China(32402492);the National Key Research and Development Program(2019YFD1000200).
Wild species of domesticated crops provide valuable genetic resources for resistance breeding.Prunus davidiana,a wild relative of peach with high heterozygosity and diverse stress tolerance,exhibits high resistance ag...
关键词：allele-specific expression aphid resistance hap-lotype genome PdaWRKY4 PEACH 
Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats
《Asian Pacific Journal of Tropical Biomedicine》2024年第6期236-244,共9页Hital Shah Tejal Gandhi 
Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in rats.Methods:Wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betul...
关键词：NF-ΚB ISOPROTERENOL BETULIN Myocardial injury Oxidative stress INFLAMMATION Apoptosis 
SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway被引量：1
《Acta Biochimica et Biophysica Sinica》2023年第9期1479-1486,共8页Minghao Fan Zhenmei Chen Weiqing Shao Yiran Chen Zhifei Lin Chenhe Yi Yitong Li Lu Lu Yu Zhou Jing Lin 
supported by the grants from the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160009);the Zhejiang Provincial Medical and Health Science and Technology Project(No.2020KY927);the National Natural Science Foundation of China(No.82000605).
Lenvatinib has become the first-line therapy in advanced hepatocellular carcinoma(HCC),but its efficacy is still limited because of the inevitable development of resistance.It has been reported that cellular cholester...
关键词：hepatocellular carcinoma SREBP2 lenvatinib BETULIN CHOLESTEROL INTERLEUKIN-1Β 
Epigenetic modification associated with climate regulates betulin biosynthesis in birch
《Journal of Forestry Research》2023年第1期21-35,共15页Jiang Wang Bowei Chen Shahid Ali Tianxu Zhang Yu Wang He Zhang Lishan Wang Yonglan Zhang Linan Xie Tingbo Jiang Jing Yin Heike W.Sederoff Gaurav Zinta Ronald R.Sederoff Yuhua Li Qingzhu Zhang 
the National Non-profi t Institute Research Grant of the Chinese Academy of Forestry(CAFYBB2019ZY003);the National Natural Science Foundation of China(31871220 and 31801444);the Innovation Project of State Key Laboratory of Tree Genetics andBreeding(Northeast Forestry University)(2013A06);the Fundamental Research Funds for the Central Universities(2572017DA06 and 2572020DP01);Heilongjiang Provincial Natural Science Foundation of China(LH2021C005).
The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unc...
关键词：EPIGENETICS DNA methylation BETULIN bHLH9 transcription factor HORMESIS Climate change Secondary metabolite 
Research Progress on Pharmacological Effects of Betulin
《Medicinal Plant》2022年第4期78-80,共3页Shuxin LI Chenghao JIN 
Supported by Talent Training Project of the Central Support Fund for the Reform and Development of Local Colleges and Universities(2020GSP16)。
Betulin is main component of triterpenoids in bark extract of Betula platyphylla,and has antibacterial,antiviral,liver protecting,cholagogic,antitumorus and other functions.This paper reviews the pharmacological effec...
关键词：BETULIN Pharmacological effect Alcoholic liver injury Reperfusion injury after myocardial ischemia Antitumorus effect 
Chemical Composition,Cytotoxic and Anti-arthritic Activities of Hexane Extracts of Certain Schinus Species
《Journal of Pharmacy and Pharmacology》2021年第11期378-386,共9页Heba A.S.El-Nashar Nada M.Mostafa Omayma A.Eldahshan Abdel Nasser B.Singab 
The genus Schinus(Anacardiaceae)comprises about 29 species that are utilized in both traditional and current medicine to alleviate various disorders such as rheumatism,bronchial infections,stomach upset,menstrual dist...
关键词：Schinus polygamous Schinus terebinthifolius BETULIN PHYTOL CYTOTOXIC Anti-arthritic 
Purity and Uncertainty Study of CRM Betulin by DSC被引量：2
《Natural Products and Bioprospecting》2020年第5期317-324,共8页Li Zhang Peng-Hui Yuan De-Zhi Yang Yan-Cai Bi Bin Su Bao-Xi Zhang Fu-Qing Wang Yang Lu Guan-Hua Du 
supported by National Key R&D Program of China(Grant No.2016YFC1000900);National Science and Technology Major Project of China(Grant Nos.2017ZX09101001003,2018ZX09711001-003-022,2018ZX09711001-010);National Natural Science Foundation of China(NSFC)(Grant No.81703473);CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-3-010).
Betulin(BE)can be obtained from many plants,such as those belonging Betulaceae family,and pharmacological investigations showed its notable biological properties and good potential for food and pharmaceutical developm...
关键词：BETULIN DSC Purity determination Uncertainty study 
Polypore fungi of Caucasian alder as a source of antioxidant and antitumor agents
《Journal of Forestry Research》2020年第4期1381-1390,共10页Vahide Payamnoor Mohammad Reza Kavosi Jamile Nazari 
The work was supported by Gorgan university of agricultural sciences and natural resources-grant no.93-323-28.
Macroscopic fungi on Caucasian alder wood(Alnus subcordata)were identified and tested as a source of betulin and betulinic acid(the most important metabolites of the Betulaceae family)to evaluate levels of phenols,fla...
关键词：FUNGI ALDER BETULIN Betulinic acid ANTIOXIDANT 
Analysis of Four Solvatomorphs of Betulin by TG-DTA-EI/PI-MS System Equipped with the Skimmer-Type Interface
《Natural Products and Bioprospecting》2020年第3期141-152,共12页Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du 
supported by National Key R&D Program of China(Grant No.2016YFC1000900);National Science and Technology Major Project of China(Grant Nos.2017ZX09101001003,2018ZX09711001-010);National Natural Science Foundation of China(NSFC)(Grant No.81703473);CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-3-010).
Betulin(BE)has exceedingly become a potential natural product,providing multiple pharmacological and biological activi-ties,including anti-cancer,anti-viral,and anti-inflammatory benefits.Previous research indicated t...
关键词：BETULIN Solvatomorphs TG-MS PI method 
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice被引量：11
《Acta Pharmacologica Sinica》2017年第2期201-210,共10页Yong-qin ZHOU Xiu-fang WENG Rui DOU Xiao-sheng TAN Tian-tian ZHANG Jin-bo FANG Xiong-wen WU 
The authors would like to thank the NIH tetramer core facil- ity for the CDld tetramers, Dr Qin YANG of the Institute of Pathology, Tongji Hospital, Huazhong University of Science and Technology, and Senior Engineer Yaqin Wang and Asso- ciate Prof Xia WEI of the Department of Histology and Embry- ology, Medical College of China Three Gorges University for their help and technical assistance in histological examination. This work was supported by the National Natural Science Foundation of China （No 31370885, 31000150, and 81302528） and the 973 Program from the Ministry of Science and Tech- nology of China （No 2013CB530505）.
Hedyotis hedyotidea has been used in traditional Chinese medicine for the treatment of autoimmune diseases. However, the mechanisms underlying for the effect remain unknown. We previously showed that, among 11 compoun...
关键词：Hedyotis hedyotidea BETULIN concanavalin A autoimmune hepatitis SPLENOCYTES NKT conventional T cells CYTOKINES hepatoprotective effects 
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