supported by the National Natural Science Foundation of Chongqing,China(No.cstc2019jcyj-msxm0314 of Yishu Tang);the National Key R&D Program of China(No.2017YFC0909902 of Yun Xia);the Natural Science Foundation of China(No.81501818 of Yishu Tang)。
Both hepatitis B virus X protein(HBx)and microRNA-221(miR-221)have been implicated in the development of hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).The present study demonstrates that HBx promotes HC...
Objective To investigate the mechanism of invariant natural killer T( iNKT) 2 cell improving hepatic fat deposition in nonalcoholic fatty liver( NAFL).Methods NAFL model was established by feeding C57 BL/6 J mice with...
Work in the S.I.laboratory is funded by the Spanish Ministerio de Ciencia,Innovación(MICINN),Agencia Estatal de Investigación(AEI)and Fondo Europeo de Desarrollo Regional(FEDER),RTI2018-094484-BI00,and RYC-2016-19463.EHG is the recipient of an FPI fellowship(PRE2019-087509)from the Spanish Ministry of Science and Innovation.Work in the DS laboratory is funded by the CNIC;the European Research Council(ERC-2016-Consolidator Grant 725091);the MICINN,AEI and FEDER(PID2019-108157RB);Comunidad de Madrid(B2017/BMD-3733 Immunothercan-CM);Atresmedia(Constantes y Vitales prize);and FundacióLa Maratóde TV3(201723).Work in the G.S.laboratory receives funding from the European Union’s Seventh Framework Programme(FP7/2007-2013)under grant agreement n°ERC 260464,EFSD/Lilly European Diabetes Research Programme GS,2017 Leonardo Grant for Researchers and Cultural Creators,BBVA Foundation(Investigadores-BBVA-2017)IN[17]_BBM_BAS_0066,MINECO-FEDER SAF2016-79126-R,EUIN2017-85875,Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD-3733 and Fundación AECC.IN receives funding from EFSD/Lilly(2019),EFSD Rising star(2019),and JdC-Incorporation(IJC2018-035390-I);The CNIC is supported by the Instituto de Salud Carlos III(ISCIII),the MICINN,and the Pro CNIC Foundation。
Conventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic signals.While cDCs are critical in maintaining immune balance,their role in preserving energ...