Analysis of Four Solvatomorphs of Betulin by TG-DTA-EI/PI-MS System Equipped with the Skimmer-Type Interface  

作　　者：Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du 

机构地区：[1]Beijing City Key Laboratory of Polymorphic Drugs,Center of Pharmaceutical Polymorphs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,People’s Republic of China [2]Soteria Pharmaceutical Co.,Ltd,Laiwu 271100,People’s Republic of China [3]Beijing City Key Laboratory of Drug Target and Screening Research,National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2020年第3期141-152,共12页应用天然产物（英文）

基　　金：supported by National Key R&D Program of China(Grant No.2016YFC1000900);National Science and Technology Major Project of China(Grant Nos.2017ZX09101001003,2018ZX09711001-010);National Natural Science Foundation of China(NSFC)(Grant No.81703473);CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-3-010).

摘　　要：Betulin(BE)has exceedingly become a potential natural product,providing multiple pharmacological and biological activi-ties,including anti-cancer,anti-viral,and anti-inflammatory benefits.Previous research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic solvents.This property of BE can directly affect its extraction,isolation,and preparation process.In this study,a system of thermogravimetry(TG)-differential thermal analysis(DTA)coupled with mass spectrometry(MS)with electron ionization(EI)and photoionization(PI)capability,equipped with the skimmer-type interface(i.e.,skimmer-type interfaced TG-DTA-EI/PI-MS system),as a real-time and onsite analysis technique,was employed.Then,four solvatomorphs of BE,namely,with pyridine and water(A),sec-butanol(B),n,n-dimethylformamide(DMF)(C),and isopropanol(V),were analyzed for the first time.Finally,five kinds of the main volatile gaseous species,including H2O,pyridine,sec-butanol,DMF,and isopropanol,were identified clearly.Furthermore,the multi-step desolvation processes of the four solvatomorphs of BE were revealed by this system for the first time.This system showed great potential for the rapid and accurate analysis of various solvatomorphs of natural products.

关 键 词：BETULIN Solvatomorphs TG-MS PI method 

分 类 号：R285[医药卫生—中药学]