RETROVIRIDAE

作品数：12被引量：53H指数：4
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相关作者：李希王轩刘福坤曹广文吴宗娣更多>>
相关机构：第二军医大学更多>>
相关期刊：《Chinese Medical Journal》《Frontiers of Medicine》《Virologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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The emerging roles of retromer and sorting nexins in the life cycle of viruses
《Virologica Sinica》2022年第3期321-330,共10页Yue Lu Ping He Yuxuan Zhang Yongwen Ren Leiliang Zhang 
supported by grants from National Natural Science Foundation of China(81871663 and 82072270);Undergraduate Science and Technology Innovation Plan of International Class of Clinical Medicine in Shandong First Medical University(ZYKC2019-016);Academic promotion programme of Shandong First Medical University(2019LJ001)。
Retromer and sorting nexins(SNXs)transport cargoes from endosomes to the trans-Golgi network or plasma membrane.Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses,includ...
关键词：RETROMER CORONAVIRIDAE FLAVIVIRIDAE RETROVIRIDAE Sorting nexin(SNX) 
Changes of phenotype and function of human CD4^(+)CD25^(-) T cells induced by transfection of Foxp3
《Frontiers of Medicine》2008年第4期366-369,共4页Kui WU Yutian BI Yaoli WANG Changzheng WANG 
supported by the National Natural Science Foundation of China(Grant No.30470772).
The aim of this paper is to explore the effects of transfection of Foxp3 gene on the phenotype and function of naive CD4^(+)T cells.The pMSCV-Foxp3 retroviral vec-tor encoding Foxp3 gene was transduced into the PT67 p...
关键词：Forkhead transcription factors FOXP3 pro-tein human T-lymphocytes regulatory RETROVIRIDAE 
Inhibitory effect of retroviral vector containing anti-sense Smad_4 gene on Ito cell line, LI90被引量：9
《Chinese Medical Journal》2004年第8期1170-1177,共8页徐新保 冷希圣 何振平 梁志清 林凯 魏玉华 于鑫 彭吉润 
Background Transforming growth factor-β1 (TGF-β1) exerts strong fibrogenic potential in culture-activated HSCs Smad 4 is a key intracellular mediator for the transforming growth factor-β (TGF-β) superfamily of...
关键词：genetic vectors · retroviridae · gene therapy · DNA antisense · hepatic stellate cell 
Anti-tumor effect of human endostatin mediated by retroviral gene transfer in nude mice
《Chinese Medical Journal》2002年第11期1664-1669,151,共6页王轩 刘福坤 李希 黎介寿 徐根兴 
OBJECTIVE: To explore the inhibitory effect of human endostatin gene mediated by retroviral vector on the growth of human liver carcinoma. METHODS: A recombinant retroviral plasmid containing human endostatin gene and...
关键词：Gene Therapy Animals Cell Division Cell Line Collagen ENDOSTATINS Endothelium  Vascular Gene Transfer Techniques MICE Mice  Nude Neoplasms  Experimental Peptide Fragments RETROVIRIDAE Transfection 
Tumor cell-specific gene transfer with retroviral vectors displaying single-chain antibody
《Chinese Medical Journal》2002年第7期1064-1069,153,共6页汤宇澄 李煜 钱关祥 
ThisresearchissupportedbyNationalScienceFoundationofChina(No .863 Z2 0 0 1 0 4)
OBJECTIVE: To specifically deliver the therapeutic gene to cancer cells and construct target retroviral vectors by inserting the single-chain variable antibody fragment into the retroviral envelope. METHODS: Single-ch...
关键词：Gene Therapy Gene Transfer Techniques Genetic Vectors Hela Cells Humans Immunoglobulin Fragments NEOPLASMS Research Support  Non-U.S. Gov't RETROVIRIDAE 
Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation被引量：17
《Cell Research》2002年第2期123-132,共10页MIN ZHANG, BAO HuI ZHANG, LI CHEN, WEI AN1 Institute of Sports Medicine, The Third Hospital, Peking University, Beijing 100083, China 2Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054, China 
This work was kindly supported by Na-tional Natural Science Foundation of China(No.39670308)
To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we establishe...
关键词：Animals Blotting  Northern Blotting  Southern Blotting  Western Cell Division Cell Survival Cells  Cultured Cyclic GMP Dose-Response Relationship  Drug Flow Cytometry Free Radicals Genetic Vectors Heme Oxygenase (Decyclizing) Heme Oxygenase-1 Humans Hydrogen Peroxide MAP Kinase Signaling System Male Membrane Proteins Muscle  Smooth Myocytes  Smooth Muscle OXIDANTS Oxidative Stress Oxygen Phosphorylation RATS Rats  Sprague-Dawley Research Support  Non-U.S. Gov't RETROVIRIDAE Time Factors Transfection 
A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD34^+ cells to improve combination chemotherapy tolerance被引量：3
《Chinese Medical Journal》2001年第1期25-29,共5页王季石 陈子兴 夏学鸣 卢大儒 薜京伦 阮长耿 
theNationalNaturalScienceFoundationofChina (No 39770 331)
OBJECTIVE: To study whether human umbilical cord blood CD34+ cells transduced with human aldehyde dehydrogenase class-1 (ALDH-1) and multidrug resistance gene (MDR1) have increases resistance to 4-Hydroperoxycyclo-pho...
关键词：Aldehyde Dehydrogenase Animals Antigens  CD34 Antineoplastic Combined Chemotherapy Protocols Cell Line Drug Resistance  Neoplasm Fetal Blood Genetic Vectors Hematopoietic Stem Cells Humans ISOENZYMES Mice P-Glycoprotein Research Support  Non-U.S. Gov't RETROVIRIDAE 
Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87被引量：11
《World Journal of Gastroenterology》2001年第4期559-562,共4页Xiao-Chao Wei Xin-Juan Wang Kai-Chen Lei Zhang Yu Liang Xin-Li Lin Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing 100083,ChinaProtein Studies,Oklahoma Medical Research Foundation,Oklahoma City,OK 73104,USA 
the National Natural Science Foundation of China,No.39870850
AIM: To clone the cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) into a tetracycline-regulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma ...
关键词：Stomach Neoplasms 3T3 Cells Animals Anti-Bacterial Agents APOPTOSIS Apoptosis Regulatory Proteins DOXYCYCLINE Gene Expression Regulation  Neoplastic Genetic Vectors Humans Jurkat Cells Membrane Glycoproteins Mice Research Support  Non-U.S. Gov't RETROVIRIDAE Transfection Tumor Necrosis Factor-alpha 
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma被引量：2
《Cell Research》1999年第3期225-235,共11页GAODINGCHENG WEIAN 等 
The therapeutic effect of herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) system on hepatocellular carcinoma was studied in this experiment. The tk-containing retroviral recombinants were used to infect...
关键词：Gene Therapy Animals Blotting  Southern Carcinoma  Hepatocellular Cell Death GANCICLOVIR Gene Expression HETEROCHROMATIN Humans Liver Neoplasms Male MICE Mice  Inbred BALB C Mice  Nude Microscopy  Electron Research Support  Non-U.S. Gov't RETROVIRIDAE Simplexvirus Thymidine Kinase Transfection Tumor Cells  Cultured 
Transduction of human hepatocellular carcinoma cells with human γ-interferon gene via retroviral vector被引量：9
《World Journal of Gastroenterology》1998年第3期30-33,共4页QIAN Shu Bing and CHEN Shi Shu 
AIM To investigate the therapeutic potential of gamma interferon (IFN γ) gene modified human hepatocellular carcinoma (HCC) cells. METHODS The IFN γ gene was introduced retrovirally into four HCC cell lines. S...
关键词：carcinoma hepatocellular/therapy INTERFERON Ⅱ/genetics RETROVIRIDAE immunotherapy adoptive 
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