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This is a correction to:Shijia Bi and others,SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer,Protein&Cell,Volume 11,Issue 7,July 2020,Pages 483-504,https://doi.org/10.1007/s13238-020-00728-4 Th...
supported by grants from National Natural Science Foundation of China(31971165 and 82173465);Leading Talents Program of Gusu District(ZXL2022454);Jiangsu Provincial Outstanding Postdoctoral Program(2023ZB254),China.
Objective:To investigate the impact of SWI/SNF complex on heterochromatin DNA damage repair after exposure to X-ray irradiation,in order to explore the underlying mechanism.Methods:NIH3T3 and MRC5 cells were treated w...
supported by the Chinese Academy of Sciences,including the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27040203 to C.-G.D.and XDB27040000 to J.K.Z);in part by a grant from the National Key Research and Development Project of China(2016YFE0108800 to Q.Q.L.)。
Heterochromatin is widespread in eukaryotic genomes and has diverse impacts depending on its genomic context.Previous studies have shown that a protein complex,the ASI1-AIPP1-EDM2(AAE)complex,participates in polyadeny...
the Department of Science and Technology(DST-SERB),India,for funding(DST grant number:ECR/2016/001740);University Grants Commission,India,for fellowship support。
In eukaryotic genome biology,the genomic organization inside the three-dimensional(3D)nucleus is highly complex,and whether this organization governs gene expression is poorly understood.Nuclear lamina(NL)is a filamen...
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100);the National Key R&D Program of China(2018YFC2000100,2018YFA0107203,2017VFA0102802,2017YFA0103304,2015CB964800,2019YFA0110100);the National Natural Science Foundation of China(81861168034,81921006,81625009,91749202,31671429,91949209,81671377,91749123,81822018,81870228,31801010,81922027,81701388);Program of Beijing Municipal Science and Technology Commission(Z191100001519005);Beijing Natural Science Foundation(Z190019);Beijing Municipal Commission of Health and Family Planning(PXM2018_026283_000002);Advanced Innovation Center for Human Brain Protection(3500-1192012);the Key Research Program of the Chinese Academy of Sciences(KFZD-SW-221);K.C.Wong Education Foundation(GJTD-2019-06,GJTD-2019-08);Youth Innovation Promotion Association of CAS(2016093);the State Key Laboratory of Stem Cell and Reproductive Biology;the State Key Laboratory of Membrane Biology;P.G.was supported by MAPHRE and Fundacion Pedro Guillen.
Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadian clock proteins underlies stem cell aging and whether th...
Stem cell aging is one of the leading theories of aging and is gaining momentum in recent years with the development of new technologies to study stem cells(Schultz&Sinclair,2016).In the stem cell aging theory,the age...
SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that ...
supported by grants from National Science Foundation of China(31771547);Chinese National Special Grant for Transgenic Crops(2016ZX08009003-005)。
In higher plants,lateral organs are usually of determinate growth.It remains largely elusive how the determinate growth is achieved and maintained.Previous reports have shown that Arabidopsis PEAPOD(PPD)proteins suppr...
Heterochromatin,being transcriptionally inactive,is the highly condensed form of chromatin that is associated with Histone H3 lysine 9 methylation (H3K9me)and DNA methylation in eukaryotic cells.In fission yeast and a...
the National Key R&D Program (2016YFAOSO0700 to H.L.,and 2016YFA0500800 to Q.S.);the National Science Foundation of China (31725014,91753203 to H.L.,and 31571322 to Q.S.);the Tsinghua University Initiative Scientific Research Program (to H.L.and Q.S.).Q.S.and P.L.are supported by the 1000 Young Talent Program of China.
Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heteroc...