云南高校图书馆联盟文献共享服务平台- CLOCK

CLOCK: 作品数：542被引量：741H指数：14; 导出分析报告; 相关领域：电子电信更多>>; 相关作者：江舟王正荣汪宇辉刘延友童建更多>>; 相关机构：苏州大学四川大学复旦大学湖北中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

昼夜节律紊乱促进子宫内膜癌进展的作用机制研究: 《中国生育健康杂志》2025年第1期51-55,69,共6页赵乐王朝霞张三元; 山西省基础研究自然科学研究面上项目(20210302123244)。; 目的探讨昼夜节律紊乱对子宫内膜癌节律基因CLOCK表达的影响及其参与疾病进展的可能机制。方法按照患者的年龄、孕产次、工作经历、教育信息及环境等背景匹配筛选出有夜班史的子宫内膜样腺癌6例为节律异常组,无夜班史6例为节律正常组,采...; 关键词：子宫内膜癌生物钟基因节律基因CLOCK 上皮-间质转化

近日节律基因Clock调控小鼠肠道菌群及肠道结构影响NAFLD的发生发展: 《兰州大学学报(自然科学版)》2025年第1期109-117,共9页陈晓惠任欣欣雷艳李敏倩王芳王蓓杨淑红; 甘肃省自然科学基金项目(22JR11RA175);国家卫生健康委员会时间生物学重点实验室开放课题(NHCC-2022-03);甘肃省高等学校青年博士支持项目(2024QB-035)。; 构建肝-肠轴部位敲低Clock基因的C57BL/6小鼠,通过西方饮食喂养建立非酒精性脂肪肝疾病(NAFLD)型,检测Clock基因对肝脏和肠道组织的影响,通过16S rDNA测序分析小鼠肠道微生物组学变化.结果显示,敲低Clock基因会加剧小鼠NAFLD症状,表现...; 关键词：非酒精性脂肪肝疾病 CLOCK基因肠道菌群肠道紧密连接

补肾活血方对应力条件下终板软骨细胞生物节律分子BMAL1与CLOCK表达的影响: 《湖北中医药大学学报》2024年第6期10-13,共4页赵柯熊勇周帅琪谢榕杜雨轩王戈文梁煜鹏金哲峰朱立国展嘉文; 国家自然科学基金项目(项目编号:82274557)。; 目的观察补肾活血方对应力退变终板软骨细胞(CEPCs)生物节律关键分子的调控作用。方法采用地塞米松同步化处理,检测CEPCs 48 h内节律分子表达变化探索不同应力条件(5%或10%牵张力)对CEPCs节律分子表达的影响。筛选异常应力条件,设置空...; 关键词：补肾活血方终板软骨细胞生物节律应力退变应力

Multiple wavelength frequency stabilization with a single transfer cavity for mercury optical lattice clock: 《Chinese Optics Letters》2024年第10期100-105,共6页Li Ma Qixin Liu Haiyang Song Jianfang Sun Zhen Xu; supported by the National Natural Science Foundation of China(Nos.11874371,91436105,and 12104474);the Shanghai Science and Technology Program,China(No.22ZR1471000);the Strategic Pilot Science and Technology Project of the Chinese Academy of Sciences,China(No.XDB21030200)。; A simple and robust multiple wavelength frequency stabilization system is demonstrated using a single transfer cavity and a1062-nm ultra-stable laser for all the lasers used in a mercury optical lattice clock.Offset s...; 关键词：laser frequency stabilization Fabry–Perot cavity optical lattice clock Pound–Drever–Hall locking

小檗碱介导BMAL1:CLOCK复合体调控糖脂代谢改善脂肪胰岛素抵抗的效应机制被引量：2: 《中国中药杂志》2024年第17期4586-4596,共11页王颖徐中华延李科崔灿刘伟华肖汉月涂珺; 国家自然科学基金项目(82160838,81960809);江西中医药大学校级科技创新团队发展计划项目(CXTD22007)。; 探究小檗碱介导脑和肌肉芳香烃受体核转位样蛋白1(brain and muscle arnt-like 1,BMAL1):昼夜自发输出周期蛋白kaput(circadian locomotor output cycles kaput,CLOCK)复合体,调控糖脂代谢改善脂肪胰岛素抵抗(insulin resistance,IR)的...; 关键词：胰岛素抵抗脂代谢糖代谢 BMAL1:CLOCK复合体小檗碱

High-precision services of BeiDou navigation satellite system(BDS):current state,achievements,and future directions被引量：2: 《Satellite Navigation》2024年第3期19-38,共20页Weiguang GAO Wei Zhou Chengpan Tang Xingxing Li Yongqiang Yuan Xiaogong Hu; sponsored by the National Natural Science Foundation of China (Grant Nos.41974041,42374044).; With the rapid development of technologies such as autonomous driving and robotic navigation,the demand for accurate and reliable positioning results with BDS has increased.The current status and future development of...; 关键词：BeiDou navigation satellite system Precise point positioning PPP-B2b LoW-earth-orbit PPP-RTK PPP-AR ORBIT CLOCK

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1: 《Acta Pharmacologica Sinica》2024年第9期1793-1808,共16页Chun-yan Duan Yue Li Hao-yu Zhi Yao Tian Zheng-yun Huang Su-ping Chen Yang Zhang Qing Liu Liang Zhou Xiao-gang Jiang Kifayat Ullah Qing Guo Zhao-hui Liu Ying Xu Jun-hai Han Jiajie Hou Darran P O’Connor Guoqiang Xu; National Key R&D Program of China(2019YFA0802401);National Natural Science Foundation of China(31971353);National Center for International Research(2017B01012);Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.; The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock,which maintains a~24 h internal oscillation.As the core element of the circadian clock,BM...; 关键词：BMAL1 circadian rhythm PROTEOMICS transcriptional activity UBIQUITINATION UBR5

基于Early Clock Flow方式的时钟树综合物理设计: 《集成电路应用》2024年第9期1-3,共3页杨沛邹文英陈柱江李小强; 阐述时钟树综合作为芯片后端物理设计的核心步骤,成为制约芯片设计技术发展的关键。基于业界主流设计工具Innovus软件的早期时钟流程Early Clock Flow,改进设计流程,优化时钟树综合结果。与传统时钟树综合对比,时钟单元数量减少3.2%,走...; 关键词：电路设计早期时钟时钟树综合(CTS) useful skew 物理设计后端设计

DNA methylation clocks for estimating biological age in Chinese cohorts被引量：2: 《Protein & Cell》2024年第8期575-593,共19页Zikai Zheng Jiaming Li Tianzi Liu Yanling Fan Qiao-Cheng Zhai Muzhao Xiong Qiao-Ran Wang Xiaoyan Sun Qi-Wen Zheng Shanshan Che Beier jiang Quan Zheng Cui Wang Lixiao Liu Jiale Ping Si Wang Dan-Dan Gao Jinlin Ye Kuan Yang Yuesheng Zuo Shuai Ma Yun-GuiYang Jig Qu Feng Zhang Peilin Jia Guang-Hui Liu Weiqi Zhang; supported by the National Key Research and Development Program of China(2021YFF1201000,2022YFA1103700);the Quzhou Technology Projects(2022K46);the National Natural Science Foundation of China(Grant Nos.32121001,81921006,82125011,92149301,82361148131,82192863);the National Key Research and Development Program of China(2020YFA0804000,2020YFA0112200,the STI2030-Major Projects-2021ZD0202400,2021YFA1101000);the National Natural Science Foundation of China(Grant Nos.92168201,92049304,92049116,82122024,82071588,32000510,8236114813082271600,82322025,82330044,32341001);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38010400);the Science and Technology Service Network Initiative of Chinese Academy of Sciences(KFJSTS-QYZD-2021-08-001);the Beijing Natural Science Foundation(Z230011,5242024)the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301,CAS-WX2022SDC-XK14,CAS-WX2021SF-0101);New Cormerstone Science Foundation through the XPLORER PRIZE(2021-1045);YouthInnovation Promotion Association of CAS(E1CAZW0401,2022083);Excellent Young Talents Program of Capital Medical University(12300927);the Project for Technology Development of Beijing-affliated Medical ResearchInstitutes(11000023T000002036310);ExcellentYoung Talents Training Program for the Construction of Beijing Municipal University Teacher Team(BPHR202203105);Young Elite Scientists Sponsorship Program by CAST(2021QNRC001);Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY202X-X).; Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics dat...; 关键词：DNA methylation aging clock AGING age prediction

A 56 Gb/s DAC-DSP-based transmitter with adaptive retiming clock optimization using inverse-PR-based PD achieving 8-UI converge time in 28-nm CMOS: 《Science China(Information Sciences)》2024年第8期343-344,共2页Shubin LIU Chenxi HAN Xiaoteng ZHAO Yuhao ZHANG Shixin LI Hongzhi LIANG Lihong YANG Zhangming ZHU; supported by National Key Research and Development Program of China(Grant No.2022YFB4401904);National Natural Science Foundation of China(Grant Nos.62374126,62021004,62227816)。; With the growing demand for communication bandwidth,transmitters(TXs)are operating at higher rates,compressing thetiming margin for the last 4:1 or 2:1 multiplexer(MUX).To alleviate the timing constraints,the retimer ...; 关键词：INVERSE OPTIMIZATION timing

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