云南高校图书馆联盟文献共享服务平台- BMAL1

BMAL1: 作品数：183被引量：440H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：夏中元丁海丽金风许伟红吴华香更多>>; 相关机构：华中科技大学苏州大学山西医科大学贵州医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金湖北省自然科学基金浙江省自然科学基金陕西省自然科学基金更多>>

IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis: 《Genes & Diseases》2025年第3期584-598,共15页Xinyue Li Hong Zhang Fan Yu Shuting Xie Tongyu Wang Rong Zhang Guangzhong Xu Liang Wang Yeping Huang Cheng Hu; supported by grants from the National Science Foundation of China(No.81974118,82325010);The Shanghai Outstanding Academic Leaders(China)(No.20XD1433300);the Shuguang Project of China(21SG11);the Innovative Research Team of High-level Local Universities in Shanghai,China(No.SHSMU-ZDCX20212700);the Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education(China)(No.2023ZKZD17);the Shanghai Research Center for Endocrine and Metabolic Diseases(China)(No.2022ZZ01002);the Shanghai Sixth People’s Hospital Foundation(China)(No.ynqn202105).; Non-alcoholic fatty liver disease(NAFLD)is a hepatic metabolic syndrome arisingfrom lipid metabolic imbalance,with its prevalence increasing globally.In this study,weobserved a significant up-regulation of interferon ...; 关键词：Brain and muscle ARNT-Like 1 Hepatic steatosis Interferon regulatory factor 8 LIPOGENESIS Non-alcoholic fatty liver disease Peroxisome proliferator-activated receptorγ Transcriptional regulation

Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis: 《International Journal of Oral Science》2025年第1期122-132,共11页Yazheng Wang Rui Li Qingyuan Ye Dongdong Fei Xige Zhang Junling Huang Tingjie Liu Jinjin Wang Qintao Wang; supported by the National Natural Science Foundation of China(Nos.82170955,82101064);the Xinfei Program funded by Fourth Military Medical University。; Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift w...; 关键词：BMAL1 NLRP3 PERIOD

Signaling pathway mechanisms of circadian clock gene Bmal1regulating bone and cartilage metabolism:a review: 《Bone Research》2025年第1期35-47,共13页Yiting Ze Yongyao Wu Zhen Tan Rui Li Rong Li Wenzhen Gao Qing Zhao; National Natural Science Foundation of China(82171003 and 82171002);Research and Develop Program of West China Hospital of Stomatology Sichuan University(NO.LCYJ-2022-YY-1)。; Circadian rhythm is ubiquitous in nature.Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network,and regulate a variety of physiological and pathological processes,i...; 关键词：BMAL1 METABOLISM CARTILAGE

BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise: 《Journal of Sport and Health Science》2025年第1期107-129,共23页Mingwei Guo Fei Shen Xiaozhen Guo Jun Zhang Ying Ma Xia Wu Hui Zuo Jing Yao Yepeng Hu Dongmei Wang Yu Li Jin Li Jin Qiu Jian Yu Meiyao Meng Ying Zheng Xin Chen Mingkai Gong Kailin Liu Ling Jin Xiangyu Ren Qiang Zhang Yu Zhao Xuejiang Gu Feixia Shen Dali Li Liangcai Gao Chang Liu Fei Zhou Mian Li Jiqiu Wang Shuzhe Ding Xinran Ma Jian Lu Cen Xie Junjie Xiao Lingyan Xu; supported by funds from National Key Research and Development Program of China (2019YFA0904500 to LX, 2023YFA1800400 to LX, and 2018YFE0113500 to JX);the National Natural Science Foundation of China (82301777 to MG, 32222024 to LX, 32325024 to XM, 32071148 to LX, and 91957116 to CX);Fundamental Research Funds for the Central Universities, Science and Technology Commission of Shanghai Municipality (21140904300 to XM and 22ZR1421200 to LX);Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JX);Key Project of 2022 Higher Education Scientific Research Planning Project of China Association of Higher Education (22TY0218 to FS);Youth Fund for Humanities and Social Sciences Research of the Ministry of Education (22YJC890023 to FS);Postdoctoral Fellowship Program of CPSF (GZB20230219 to MG);China Postdoctoral Science Foundation (2023M741183 to MG);ECNU public platform for Innovation (011).; Background: Resistance exercise leads to improved muscle function and metabolic homeostasis.Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.Methods: Human volunteers w...; 关键词：Daily variance CIRCADIAN Muscle strength Metabolic benefits Resistance exercise

高脂饮食对甲状腺生物钟基因Bmal1敲除小鼠甲状腺形态和功能及糖脂代谢的影响: 《中华医学杂志》2025年第5期371-378,共8页叶绮婷张诗丽冯雯雯关海霞; 国家自然科学基金(82170803)。; 目的探究高脂饮食(HFD)喂养后甲状腺生物钟基因Bmal1敲除后小鼠甲状腺形态和功能发生的变化,并分析其对小鼠糖脂代谢的影响。方法构建甲状腺生物钟基因Bmal1特异性敲除小鼠(T-Bmal1^(-/-))模型(敲除组,n=10),并以无甲状腺过氧化物酶-环...; 关键词：小鼠基因敲除甲状腺 BMAL1 生物钟糖脂代谢

Circadian clock regulates immune checkpoint inhibitor efficacy: 《Acta Pharmaceutica Sinica B》2025年第2期1183-1185,共3页Yining Niu Motao Zhu; supported by grants from the National Key R&D Program of China(2022YFA1206100 and 2021YFA1201100);the National Natural Science Foundation of China(32271449);CAS Project for Young Scientists in Basic Research(YSBR-036,China);Beijing Natural Science Foundation(Z230008,China).; Immunotherapy remains one of the most promising strategies for cancer treatment,with ICIs at the forefront of this innovation1.However,patient response to ICIs is highly variable,highlighting the urgent need to enhanc...; 关键词：Clock disruption Circadian rhythm Anti-programmed death ligand 1 Myeloid-derived suppressor cells IMMUNOTHERAPY Immune checkpoint inhibitors BMAL1 Cancer treatment

七氟醚可逆性下调糖尿病模型大鼠心肌生物钟蛋白BMAL1的表达: 《基础医学与临床》2025年第1期70-75,共6页刘慧韩冲芳秦小英于菁贺建东杨文曲; 山西白求恩医院优秀青年启动基金(2019YJ11)。; 目的观察七氟醚(SEV)对糖尿病大鼠心肌生物钟基因芳香烃受体核转运样蛋白1(BMALl1)表达的影响,并探讨其变化规律。方法雄性SD大鼠60只,体质量200~250 g,将正常大鼠分为吸氧组(NC)、吸七氟醚组(SEV);常规建立糖尿病模型,建立成功后分为...; 关键词：七氟醚糖尿病心肌芳香烃受体核转运样蛋白1(BMAL1) 泛素特异性肽酶9X(USP9X)

黄芪建中汤对心源性恶病质大鼠白色脂肪消耗及BMAL1/REV-ERBα节律环路的影响: 《中成药》2024年第12期3961-3967,共7页吴涛曲一玮徐圣洁李晓王咏马度芳; 国家自然科学基金项目(82004280,82074388,82104797)。; 目的探究黄芪建中汤对心源性恶病质大鼠白色脂肪组织(WAT)过度消耗的影响以及BMAL1/REV-ERBα节律环路在其中的作用。方法将40只Dahl盐敏感大鼠随机分为对照组、正常节律组、正常节律中药组、颠倒节律组、颠倒节律中药组,每组8只,除...; 关键词：黄芪建中汤心源性恶病质脂肪消耗昼夜节律环路白色脂肪棕色化

小檗碱介导钟控基因调节糖脂代谢改善肝细胞胰岛素抵抗的分子机制被引量：2: 《中国中药杂志》2024年第23期6368-6377,共10页延李科崔灿王颖朱水兰徐中华肖汉月刘伟华涂珺; 国家自然科学基金项目(82160838,81960809);江西中医药大学校级科技创新团队发展计划项目(CXTD22007)。; 探讨小檗碱介导脑和肌肉芳香烃受体核转运样蛋白1基因(brain and muscle arnt-like 1,BMAL1)为中心的钟控基因调节代谢网络改善肝细胞胰岛素抵抗(insulin resistance, IR)的分子机制。优化建立地塞米松诱导肝IR-HepG2模型,5、10、20μmo...; 关键词：2型糖尿病胰岛素抵抗脑和肌肉芳香烃受体核转运样蛋白1基因(BMAL1) 时钟调控基因小檗碱糖脂代谢

补肾活血方对应力条件下终板软骨细胞生物节律分子BMAL1与CLOCK表达的影响: 《湖北中医药大学学报》2024年第6期10-13,共4页赵柯熊勇周帅琪谢榕杜雨轩王戈文梁煜鹏金哲峰朱立国展嘉文; 国家自然科学基金项目(项目编号:82274557)。; 目的观察补肾活血方对应力退变终板软骨细胞(CEPCs)生物节律关键分子的调控作用。方法采用地塞米松同步化处理,检测CEPCs 48 h内节律分子表达变化探索不同应力条件(5%或10%牵张力)对CEPCs节律分子表达的影响。筛选异常应力条件,设置空...; 关键词：补肾活血方终板软骨细胞生物节律应力退变应力

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