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作 者:Yining Niu Motao Zhu
机构地区:[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China
出 处:《Acta Pharmaceutica Sinica B》2025年第2期1183-1185,共3页药学学报(英文版)
基 金:supported by grants from the National Key R&D Program of China(2022YFA1206100 and 2021YFA1201100);the National Natural Science Foundation of China(32271449);CAS Project for Young Scientists in Basic Research(YSBR-036,China);Beijing Natural Science Foundation(Z230008,China).
摘 要:Immunotherapy remains one of the most promising strategies for cancer treatment,with ICIs at the forefront of this innovation1.However,patient response to ICIs is highly variable,highlighting the urgent need to enhance their efficacy in clinical settings2.Addressing this challenge is critical for advancing the impact of immunotherapy in oncology.
关 键 词:Clock disruption Circadian rhythm Anti-programmed death ligand 1 Myeloid-derived suppressor cells IMMUNOTHERAPY Immune checkpoint inhibitors BMAL1 Cancer treatment
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