Treatment of nasopharyngeal carcinoma and prevention of nonalcoholic Wernicke’s disease:A case report and review of literature  

作　　者：Yu-Yang Ma Xiao-Chan He Yu Gao Tian-Tian Ma Gong Cheng Chang-Wu Yue 

机构地区：[1]Yan’an Key Laboratory of Microbial Drug Innovation and Transformation,School of Basic Medicine,Yan’an University,Yan’an 716000,Shaanxi Province,China [2]Department of Cardiology,Second Division,Shaanxi Provincial People’s Hospital,Xi’an 710000,Shaanxi Province,China [3]Xi’an Honghui Hospital,Xi’an Jiaotong University,Xi’an 710000,Shaanxi Province,China

出　　处：《World Journal of Clinical Cases》2024年第24期5628-5635,共8页世界临床病例杂志

摘　　要：BACKGROUND Wernicke encephalopathy is a neurological disorder caused by thiamine deficiency,commonly seen in alcoholic populations but also involving other circumstances that may lead to thiamine deficiency.The recognition of Wernicke encephalopathy often depends on clinicians’keen ability to detect its typical triad of features;however,most cases do not present with the full constellation of signs,which complicates the timely identification of Wernicke encephalopathy.CASE SUMMARY This case report describes a patient with nasopharyngeal carcinoma who developed abnormal ocular function and ataxia following concurrent chemoradiotherapy,without a history of alcohol abuse.With the aid of radiological examinations,he received a timely diagnosis and treatment;however,his symptoms did not fully resolve during follow-up.CONCLUSION For patients with malignant tumors exhibiting neurological symptoms,clinicians should consider the possibility of Wernicke encephalopathy and provide prophylactic thiamine therapy.

关 键 词：Nasopharyngeal carcinoma Non-alcoholic Wernicke’s disease Wernicke’s encephalopathy NEUROLOGICAL Case report 

分 类 号：R735.7[医药卫生—肿瘤]