ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc  

作　　者：Ken Chen Zuozhen Tian Motomi EnomotoIwamoto Yejia Zhang 

机构地区：[1]Departments of Physical Medicine&Rehabilitation,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19146,USA [2]School of Dental Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA [3]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]Department of Orthopedics,University of Maryland School of Medicine,Baltimore,MD 21201,USA [5]Section of Rehabilitation Medicine,Corporal Michael J.Crescenz Veterans Affairs Medical Center,Philadelphia,PA 19104,USA

出　　处：《Genes & Diseases》2025年第3期54-56,共3页基因与疾病(英文)

摘　　要：Dear Editor ADAM8(ADAM metallopeptidase domain 8,aka MS2/CD156/CD156a)is a membrane-anchored proteinase.ADAM8 and its proteolytic product,fibronectin fragments,are elevated in degenerative human intervertebral discs(IVDs).1 Pathological fibronectin fragments can trigger further disc degeneration.ADAM8 proteolytic activities and fibronectin fragments may accelerate degenerative disc disease,a common clinical problem leading to tremendous socioeconomic burdens in the United States.

关 键 词：degenerative human intervertebral discs ivds degenerative disc diseasea Intervertebral Disc fibronectin fragments DEGENERATION Adam Fibronectin Fragments Gene Expression 

分 类 号：R681.5[医药卫生—骨科学]