Identification of ferroptosis/autophagy-related genes and potential underlying mechanisms involved in the effect of BMSC senescence on the osteogenic differentiation of aging BMSCs  

作　　者：Kai Chen Huaqiang Tao Haixiang Xiao Miao Chu Pengfei Zhu Shujun Lv Lixin Huang Dechun Geng 

机构地区：[1]Department of Orthopedics,Hai’an People’s Hospital,Hai’an,Jiangsu 226600,China [2]Department of Orthopedics,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215000,China [3]Department of Orthopaedics,Dushu Lake Hospital Affiliated to Soochow University,Suzhou,Jiangsu 215000,China [4]Department of Orthopaedics,Yixing People’s Hospital,Yixing,Jiangsu 214200,China

出　　处：《Genes & Diseases》2025年第1期130-133,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.82072425);the Natural Science Foundation of Jiangsu Province,China(No.BK20220059);the Jiangsu Medical Research Project(China)(No.ZD2022021)。

摘　　要：Bone mesenchymal stem cells(BMSCs)are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions.They play an important role in bone regenerative medicine.The senescence of BMsCs might cause accelerated degeneration of bone tissue.Autophagy is a process in which cellular homeostasis is maintained by autophagosomes and lysosomes.It could control the function and senescence of BMSCs during bone aging and might be a therapeutic target for treating diseases during aging.1 Ferroptosis is a regulated cell death process.2 The inhibition of ferroptosis in mesenchymal stem cells could reduce cell injury and might have great therapeutic value.3-5.

关 键 词：DEGENERATION HOMEOSTASIS AGING 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]