AZOXYMETHANE

作品数：15被引量：27H指数：3
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相关领域：医药卫生更多>>
相关作者：郑雅文更多>>
相关机构：河北中医学院台湾大学更多>>
相关期刊：《Food and Nutrition Sciences》《Food Quality and Safety》《Chinese Journal of Integrative Medicine》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice被引量：2
《Chinese Journal of Integrative Medicine》2024年第7期623-632,共10页YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua SU Lian-lin YAN Shuai 
Supported by the Natural Science Foundation of Nanjing University of Chinese Medicine(No.XZR2020038);Science and Technology Innovation Project of Suzhou Medical and Health Care(No.SKJY2021136);Fifth Batch of Gusu Health Personnel Training Project in Suzhou(No.GSWS2020085)。
Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of metabolomics.Methods Forty male C57BL/6 mice were randomly divided into normal control(NC),a...
关键词：colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry AZOXYMETHANE dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine 
Probiotic Lactobacillus brevis CLB3 prevents azoxymethane/dextran sulfate sodium-induced colon carcinogenesis in mice by reducing amino acid transport and IL-17A levels and repressing the IL-6/AKT/p-STAT3 signaling pathway
《Food Quality and Safety》2022年第4期664-677,共14页Weiyi Qian Yong Zhang Yan Long Wei Yang Rui Hu Jinping Li Yan Leng Xinjie Liu Qing X.Li Xiangyuan Wan Xun Wei 
supported by the National Key Research and Development Program of China(2018YFC2000504);the Fundamental Research Funds for the Central Universities(No.06500060);the Beijing Municipal Science and Technology Project(No.Z181100009318004),China;the USDA HATCH Project(HAW05020H),USA.
Amino acid intake plays a crucial role in the Warburg effect of cancer.Gut microbes can regulate intestinal amino acid metabolism.However,it is still unknown whether probiotic therapy can protect the host from intesti...
关键词：Lactobacillus brevis CLB3 probiotic gut microbes colorectal cancer amino acid transporter 
Ursolic acid ameliorates azoxymethane/dextran sulfate sodium-caused colorectal cancer by inhibition of Wnt signaling cascade被引量：1
《中国药理学与毒理学杂志》2021年第10期780-781,共2页ZHAO Hui SUN Qiang ZENG Sha CHEN Li LIU Mao-lun REN Shan YANG Han MING Tian-qi TAO Qiu LU Jin-jian XU Hai-bo 
National Natural Science Foundation of China(81573813,81173598);Sichuan Provincial Admin⁃istration of Traditional Chinese Medicine of China(2021MS447);Excellent Talent Program of Chengdu University of Tra⁃ditional Chinese Medicine of China(YXRC2019002,ZRYY1917);Open Research Fund of the State Key Laboratory of Southwestern Chinese Medicine Resources of China(2020XSGG006)。
OBJECTIVE To investigate the pharmacological effect of ursolic acid(UA)on colitis-associated colorectal cancer(CAC)and its underlying mechanism based on the Wnt signaling pathway.METHODS The CAC model in mice was esta...
关键词：ursolic acid colitis associated cancer Wnt/β-catenin signaling pathway 
Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model被引量：3
《World Journal of Gastroenterology》2020年第43期6782-6794,共13页Denise Sayuri Calheiros Silveira Luciana Chain Veronez Luis Carlos Lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva 
Supported by Brazilian National Council for Scientific and Technological Development(CNPq),No.140152/2013-0.
BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative colitis.Intestinal microbiota has been repor...
关键词：Lactobacillus bulgaricus Colitis-associated cancer Colorectal cancer CARCINOGENESIS Probiotics Inflammation 
An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice被引量：2
《Chinese Medical Sciences Journal》2019年第4期281-288,共8页梁玺 胡婧楠 何建明 
Supported by the Hebei Provincial Research Foundation of Health and Family Planning Commission(No.20180688)~~
Since azoxymethane(AOM)-dextran sodium sulfate(DSS)induced tumorigenesis was used to explore inflammation-associated carcinogenesis of sporadic colorectal cancer(CRC),different administration modes of AOM or DSS have ...
关键词：animal model colorectal cancer INFLAMMATION PROTOCOL 
Chemopreventive Effect of Allspice in Azoxymethane (AOM) Induced Fisher 344 Male Rats
《Food and Nutrition Sciences》2019年第2期220-234,共15页Ebube N. Onwasigwe Martha Verghese Hadyn Reid Carlissa Holden Lillian Smith Shantrell Willis Rajitha Sunkara Louis Shackelford Lloyd T. Walker 
Allspice contains phytochemicals which may have antioxidative and chemopreventive potential. The objective was to determine the effects of allspice on the AOM induced aberrant cryptic foci (ACF) in colon of Fisher 344...
关键词：ACF (Aberrant CRYPT Foci) AOM-Azoxymethane Methylene Blue FISHER 344 Male Rats CRYPT Multiplicity 
Chemopreventive Potential of Select Herbal Teas and Spices on Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats
《Food and Nutrition Sciences》2017年第3期348-366,共19页Shantrell Willis Rajitha Sunkara Zaquavis Willis Lillian Smith Fredreana Hester Hadyn Matthew Reid Priyanka Patel Meijah McCollum Louis Shackelford Ebube Onwasigwe Lloyd T. Walker Martha Verghese 
Colon cancer is the third leading cause of death in the US. Selected herbal teas and spices may reduce incidence of chronic diseases, including cancer. The objective of this study was to identify the effect of strawbe...
关键词：HERBAL Tea Antioxidant COLON Cancer AZOXYMETHANE 
Chemopreventive Potential of Canola Leafy Greens and Other Cruciferous Vegetables on Azoxymethane (AOM)-Induced Colon Cancer in Fisher-344 Male Rats
《Food and Nutrition Sciences》2016年第11期964-976,共13页R. L. Miller-Cebert J. Boateng E. Cebert L. Shackelford M. Verghese 
Cruciferous vegetables have great health benefits, and their components may be significant in the inhibition of colon tumors. The objective of this study was to investigate and compare the chemopreventive potential of...
关键词：Antioxidative Enzymes Cancer CANOLA Cruciferous Vegetables Detoxification Enzymes 
Feeding Walnuts and Peanuts Reduced Development of Azoxymethane-Induced Precancerous Lesions
《Food and Nutrition Sciences》2016年第6期440-446,共7页Hadyn Mathew Reid Rajitha Sunkara Louis Shackelford Lloyd T. Walker Martha Verghese 
Walnuts and peanuts contain phytochemicals that exhibit properties that may prevent colon cancer development. The objective was to determine the potential of walnuts and peanuts on Azoxymethane (AOM) induced Aberrant ...
关键词：Aberrant Crypt Foci (ACF) Azoxymethane (AOM) CHEMOPREVENTION Fisher 344 Rats Nuts 
Inhibition of Chemically-Induced Colon Cancer by Dietary Treatment of <i>Hibiscus sabdariffa</i>L. Dried Calyx in Rats
《Food and Nutrition Sciences》2015年第12期1174-1183,共10页Rajitha Sunkara Louis Shackelford Lloyd Walker Martha Verghese 
This study examined the chemopreventive effect of feeding sorrel calyx as meal and juice against azoxymethane (AOM) induced colon cancer in Fisher 344 male rats. Rats were randomly assigned to five different groups an...
关键词：Sorrel AZOXYMETHANE Colon Cancer Antioxidant 
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