Efficacy equivalence but hidden hurdles:Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy  

作　　者：Fang Lin Ke-Xin Ma Yue Ding Xiao-Ting Liang 

机构地区：[1]Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China [2]Shanghai Heart Failure Research Center,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China [3]Department of Organ Transplantation,Changzheng Hospital,Naval Medical University,Shanghai 200000,China [4]Shenzhen Ruipuxun Academy for Stem Cell and Regenerative Medicine,Shenzhen 515100,Guangdong Province,China

出　　处：《World Journal of Stem Cells》2025年第3期144-146,共3页世界干细胞杂志(英文)

基　　金：Supported by the Natural Science Foundation of Shanghai,No.24ZR1459300(to Xiao-Ting Liang);and the Pyramid Talent Project,No.YQ677(to Yue Ding).

摘　　要：This article discusses the study by Xiao et al,which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells(NhUCMSCs)in a mouse model of knee osteoarthritis.The results showed that NhUCMSCs alleviated osteoarthritis-related cartilage damage and inflammation comparably to both serum-cultured hUCMSCs and hyaluronic acid.While these findings broaden the potential clinical utility of N-hUCMSCs by circumventing certain drawbacks of serum-based cultures,the equivalence in efficacy raises important questions.First,how do N-hUCMSCs differ phenotypically from serum-cultured hUCMSCs,particularly in terms of proliferation rate,replicative capacity,and senescence profile?Second,what advantages might N-hUCMSCs offer over hyaluronic acid-a well-established therapy-beyond avoiding xenogeneic components and ethical concerns?Future research should focus on longterm phenotypic stability,sustained functional benefits,safety profiles,and mechanistic insights to ascertain whether N-hUCMSCs can surpass current standards of care.

关 键 词：Mesenchymal stem cells Serum-free culture OSTEOARTHRITIS Cartilage repair Regenerative medicine 

分 类 号：R73[医药卫生—肿瘤]