Battling pain from osteoarthritis:causing novel cell death  

作　　者：Yuheng Zhang Huaqiang Tao Liyuan Zhang Xueyan Li Yi Shi Wen Sun Wenlong Chen Yuhu Zhao Liangliang Wang Xing Yang Chengyong Gu 

机构地区：[1]Anesthesiology Department,Suzhou Municipal Hospital(North District),Nanjing Medical University Affiliated Suzhou Hospital,Suzhou 226000,China [2]Department of Orthopedics,the First Affiliated Hospital of Soochow University,Suzhou 226000,China [3]Orthopedics and Sports Medicine Center,Suzhou Municipal Hospital,Nanjing Medical University Affiliated Suzhou Hospital,Suzhou 226000,China [4]Department of Orthopedics,the Affiliated Changzhou Second People’s Hospital of Nanjing Medical University,Changzhou 213003,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第2期169-181,共13页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the Program of Jiangsu Science and Technology Department(Nos.BK20211083 and BE2022737);the Program of Suzhou Health Commission(Nos.GSWS2020078,SZXK202111,and GSWS2022002);the Program of Suzhou Science and Technology Department(No.SKY202306).

摘　　要：Osteoarthritis(OA)is a significant contributor to pain and disability worldwide.Pain is the main complaint of OA patients attending the clinic and has a large impact on their quality of life and economic standards.However,existing treatments for OA-related pain have not been shown to achieve good relief.The main focus is on preventing and slowing the progression of OA so that the problem of OA pain can be resolved.Pain caused by OA is complex,with the nature,location,duration,and intensity of pain changing as the disease progresses.Previous research has highlighted the role of various forms of cell death,such as apoptosis and necrosis,in the progression of pain in OA.Emerging studies have identified additional forms of novel cell death,such as pyroptosis,ferroptosis,and necroptosis that are linked to pain in OA.Different types of cell death contribute to tissue damage in OA by impacting inflammatory responses,reactive oxygen species(ROS)production,and calcium ion levels,ultimately leading to the development of pain.Evidence suggests that targeting novel types of cell death could help alleviate pain in OA patients.This review delves into the complex mechanisms of OA pain,explores the relationship between different modes of novel cell death and pain,and proposes novel cell death as a viable strategy for the treatment of these conditions,with the goal of providing scientific references for the development of future OA pain treatments and drugs.

关 键 词：OSTEOARTHRITIS PAIN cell death PYROPTOSIS ferroptosis NECROPTOSIS 

分 类 号：R73[医药卫生—肿瘤]