RNA binding motif protein 43(RBM43)suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability  

作　　者：Yao Liu Huan Feng Qi Zhao Xiao Liang Ying Wang Shuai Xiao Suqin Shen Jiaxue Wu 

机构地区：[1]State Key Laboratory of Genetic Engineering and School of Life Sciences,Fudan University,Shanghai 200438,China [2]The First Affiliated Hospital,Cancer Research Institute,Department of Gastrointestinal Surgery,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China

出　　处：《Genes & Diseases》2024年第6期20-23,共4页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China (No.82173269 to SS,81,972,712 to JW).

摘　　要：RNA binding protein is a highly conserved protein family with the RNA binding domain to bind RNA and alter RNA metabolism and function.1 Abnormal expression of RNA binding protein is common in malignant tumors and connected to migration,invasion,death,and proliferation.2 RBM43,a member of the RNA binding protein family,was verified to be considerably down-regulated in hepatocellular carcinoma(HCC),indicating poor prognosis in HCC patients.

关 键 词：METABOLISM HEPATOCELLULAR INVASION 

分 类 号：R735.7[医药卫生—肿瘤]