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Dietary oxidized cholesterol causes mucus barrier thinner via decreasing Muc2 expression in the proximal colon and increasing the abundance of mucus-degrading bacteria
《Food Science and Human Wellness》2025年第4期1251-1263,共13页Chi Yan Shouhe Huang Zixing Chen Huafang Ding Zhenyu Chen 
supported by Hong Kong Research Grants Council General Research Fund(CUHK 14102321,14103722 and 14104923)。
Oxidized cholesterol(OXC)is a harmful dietary substance.Although the consumption of OXC has been associated with colonic inflammation,related underlying mechanisms are still limited.We evaluated the influence of dieta...
关键词：Dietary oxidized cholesterol Gut microbiota Colonic inflammation Mucus barrier Western diets Inflammatory bowel diseases 
Prolonged consumption of dietary advanced lipoxidation end products contributes to renal impairment in mice through dysregulated intestinal homeostasis
《Food Science and Human Wellness》2025年第4期1291-1304,共14页Yaya Wang Lu Dong Yaozhong Hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang Yan Zhang Shuo Wang 
supported by grants from the National Natural Science Foundation of China(32030083)。
Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progress...
关键词：Dietary advanced lipoxidation end products Renal insufficiency Gut microbiota Fecal metabolites Intestinal barrier AMPK/SIRT1 signaling pathway 
Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia:a review
《Food Science and Human Wellness》2025年第3期835-849,共15页Kaina Qiao Xuewei Zhou Lili Zhang Wangang Zhang Baoguo Sun Yuyu Zhang 
supported by the National Natural Science Foundation of China(No.32122069);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910011025);China Postdoctoral Science Foundation(No.2023M730134)。
Globally,hyperuricemia is a growing health,social,and economic problem which could cause gout,chronic kidney diseases and other diseases.There are increasing evidences that a sensible diet makes sense to reduce the ri...
关键词：PURINE Metabolic mechanism Dietary types HYPERURICEMIA Personalized diet 
Inhibitory mechanism of flavonoids on dietary advanced glycation end products formation in food models
《Food and Health》2025年第2期35-38,共4页Meng-Yao Jin He Li 
financially supported by the National Natural Science Foundation of China(Grant No.32472468 and No.32001817);the Fundamental Research Program of Shanxi Province(202303021221123).
Advanced glycation end products(AGEs)are complex compounds formed through interaction of carbonyl groups from saccharides with amino groups in amino acids,proteins,lipids and nucleic acids,mainly via Maillard reaction...
关键词：flavonoid compounds advanced glycation end-products inhibitory mechanism reactive carbonyl species 
Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study
《Science China(Life Sciences)》2025年第4期1149-1157,共9页Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang 
supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0508200,2023ZD0508201);the National Natural Science Foundation of China(82100949,82470931);the Outstanding Young Investigator Award of Hunan Province(2022JJ10094);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC008)to J.H;the Intramural Research Program of the U.S.National Cancer Institute(NCI),National Institutes of Health(NIH)to D.A。
Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D),a comprehensive assessment of this relationship is currently lacking.We aimed to examine...
关键词：dietary carbohydrate type 2 diabetes prospective cohort study UK Biobank 
Dietary bile acids supplementation protects against Salmonella Typhimurium infection via improving intestinal mucosal barrier and gut microbiota composition in broilers
《Journal of Animal Science and Biotechnology》2025年第2期695-713,共19页Dan Hu Xiaoran Yang Ming Qin Li’an Pan Haiyan Fang Pengnan Chen Yingdong Ni 
The National Key R&D Program of China(2023YFD2000802)provided financial contributions。
Background Salmonella Typhimurium(S.Typhimurium)is a common pathogenic microorganism and poses a threat to the efficiency of poultry farms.As signaling molecules regulating the interaction between the host and gut mic...
关键词：Bile acid BROILER Intestinal barrier Gut microbiota Salmonella Typhimurium 
Improvement of antioxidant capability by dietary N‑acetyl cysteine supplementation alleviates bone loss induced by chronic heat stress in finisher broilers
《Journal of Animal Science and Biotechnology》2025年第2期777-796,共20页Huaiyong Zhang Herinda Pertiwi Joris Michiels Djoere Gaublomme Maryam Majdeddin Yuhuang Hou Matthieu Boone Dirk Elewaut Ivan Josipovic Jeroen Degroote 
funded by the Ghent University Special Research Fund(BOF.PDO.2022.0002.01);Projects of International Cooperation of Henan Province(232102520016);National Natural Science Foundation of Henan Province(242300420159).
Background Heat stress(HS) incidence is associated with the accumulation of reactive substances, which might be associated with bone loss. N-Acetylcysteine(NAC) exhibits strong antioxidants due to its sulfhydryl group...
关键词：Bone mass BROILERS Heat stress INTESTINE N-ACETYLCYSTEINE Oxidative stress 
Impact of dietary lysophospholipids supplementation on growth performance, meat quality, and lipid metabolism in finishing bulls fed diets varying in fatty acid saturation
《Journal of Animal Science and Biotechnology》2025年第2期831-844,共14页Meimei Zhang Haixin Bai Ruixue Wang Yufan Zhao Wenzhu Yang Jincheng Liu Yonggen Zhang Peixin Jiao 
financially supported by the National Key Research and Development Program of China(2022YFD1301105);the earmarked fund for CARS(CARS-36)。
Background The objective of this study was to evaluate the effects of dietary fatty acids(FA)saturation and lysophospholipids supplementation on growth,meat quality,oxidative stability,FA profiles,and lipid metabolism...
关键词：BULLS Fatty acids Lipid metabolism LYSOPHOSPHOLIPIDS Meat quality 
Understanding the mechanism underlying the anti-inflammatory effect of dietary flavonoids on IBD:a focus on gut microbiota and its metabolites involved in SCFA,bile acid,tryptophan and lipopolysaccharides
《Food Science and Human Wellness》2025年第2期385-403,共19页Huihui Xiong Hui Chen Lingli Chen Kehui Ouyang Suyun Lin Wenjun Wang 
supported by grants from the National Natural Science Foundation of China(31560459);Jiangxi Provincial Natural Science Foundation(20224ACB205014);The Double Thousands Talents Plan of Jiangxi(jxsq2018102075,jxsq2018102076)。
Inflammatory bowel disease(IBD)is a chronic gastrointestinal disease with a high incidence.Treatment for IBD includes medications and diet,and common anti-inflammatory medications have limitations like drug resistance...
关键词：Dietary flavonoids Inflammatory bowel disease Gut microbiota METABOLITES Mechanisms 
Long term ingestion of dietary ALEs induces metabolic disorders in mice by inducing gut dysbiosis and inhibiting AMPK/SIRT1 pathway
《Food Science and Human Wellness》2025年第2期439-449,共11页Yaya Wang Tianchang Zhang Linqing Nie Yan Zhang Junping Wang Shuo Wang 
supported by grants from the National Natural Science Foundation of China(32030083)。
Advanced lipoxidation end products(ALEs)are formed by modifying proteins with lipid oxidation products.ALEs formed in the body have been linked to diabetes and hepatic disease.However,it is not known whether ALEs form...
关键词：Dietary advanced lipoxidation end products Metabolic disorders AMPK/SITR1 signaling pathway Gut dysbiosis Intestinal barrier 
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