Prolonged consumption of dietary advanced lipoxidation end products contributes to renal impairment in mice through dysregulated intestinal homeostasis  

作　　者：Yaya Wang Lu Dong Yaozhong Hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang Yan Zhang Shuo Wang 

机构地区：[1]Tianjin Key Laboratory of Food Science and Health,School of Medicine,Nankai University,Tianjin 300071,China [2]State Key Laboratory of Food Nutrition and Safety,Key Laboratory of Food Nutrition and Safety,College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China

出　　处：《Food Science and Human Wellness》2025年第4期1291-1304,共14页食品科学与人类健康(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(32030083)。

摘　　要：Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progression of diseases,especially the accumulated effect after long-term intake.Thus,the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion,specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism.The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health,which has been verified by the pathological analysis.Further studies revealed that a high-ALEs diet disrupted the intestinal barrier,with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites.Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency.Furthermore,the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress.Thus,it was revealed that long-term intake of dietary ALE could result in renal impairment,and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.

关 键 词：Dietary advanced lipoxidation end products Renal insufficiency Gut microbiota Fecal metabolites Intestinal barrier AMPK/SIRT1 signaling pathway 

分 类 号：R57[医药卫生—消化系统]