Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer  

作　　者：Kaili Liao Yuxin Fu Shuman Guo Tingyi Qian Feifei Teng Yuhan Xu Bing Sun Hanqing Zhao Jingyan Zhang Ranhao Fan Jie Gao Xiaozhong Wang 

机构地区：[1]Jiangxi Province Key Laboratory of Immunology and Inflammation,Jiangxi Provincial Clinical Research Center for Laboratory Medicine,Department of Clinical Laboratory,The Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,Jiangxi 330006,China [2]Public Health College,Jiangxi Medical College,Nanchang University,Nanchang,Jiangxi 330006,China [3]Queen Mary College,Jiangxi Medical College,Nanchang University,Nanchang,Jiangxi 330006,China [4]The 1st Clinical Medical College,Jiangxi Medical College,Nanchang University,Nanchang,Jiangxi 330006,China [5]The 2nd Clinical Medical College,Jiangxi Medical College,Nanchang University,Nanchang,Jiangxi 330006,China

出　　处：《Genes & Diseases》2025年第3期19-22,共4页基因与疾病(英文)

基　　金：the Ethics Committee of the Second Affiliated Hospital of Nanchang University(approval numbers:(2023)CDYFYYLK(05e023)).

摘　　要：Pancreatic cancer(PC)is a commonly malignant tumor with a 5-year survival rate of only 10%.1 Cuproptosis is a newly discovered cell death mechanism closely associated with the development of tumors.This study mainly aimed to investigate cuproptosis-related genes(CRGs)and found the marker genes to construct a prognostic model for PC patients.Meanwhile,we explored their roles in immune infiltration and their relationship with drug sensitivity.After comparing the expression patterns of ten CRGs,we found these genes were differently expressed between the tumor and normal tissues.Then we further performed functional enrichment analysis,cluster analysis,and immunoeinfiltration correlation analysis.

关 键 词：immune infiltration marker genes comparing expression patterns construct prognostic model prognostic model cell death mechanism cuproptosis pancreatic cancer 

分 类 号：R735.9[医药卫生—肿瘤]