PIRNA

作品数：179被引量：271H指数：7
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Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer
《Oncology Research》2025年第5期1069-1089,共21页JINGDAN QUAN ZIXIN WAN WEI WU XINYUAN CAO JIAYUAN QIU XIAOYE LIU ZHIWEI ZHANG 
funded by the National Key Research and Development Project,grant number 2021YFE0192100;Natural Science Foundation of Hunan Province,grant numbers 2021JJ30694,2023JJ30529;Innovation and Entrepreneurship Training Program for College Students in Hunan Province,grant number S202210555254;Key Projects of Hunan Provincial Education Department,grant number 21A0285;Natural Science Foundation of Hunan Provincial and Municipal Co-Funding,grant number 2022JJ50029;Key Projects of Shaoyang Science and Technology Bureau,grant number 2021GZ031;Innovation and Entrepreneurship Training Program for College Students of the University of South China,grant numbers D202405212006326156,D202405210948392932,D202405211329047648,D202405221955420827.
One of the most prevalent malignant tumors worldwide,stomach cancer still has a high incidence and fatality rate in China,and the number of young people developing early-onset gastric cancer is steadily increasing.The...
关键词：Gastric cancer Biomarkers Immune checkpoint molecules Diagnosis MicroRNA CircRNA LncRNA PIRNA 
外周血piR-hsa-2700592在房颤患者预后中的预测研究
《陆军军医大学学报》2025年第6期551-560,共10页杨蕾 邬娜 杨岚清 陈彦秀 陈兴华 袁志权 李成英 吴龙 曾雨虹 王煜 钟理 杨敬源 李亚斐 
国家自然科学基金面上项目(82073649)。
目的探究外周血piR-hsa-2700592与房颤患者全因死亡和卒中结局的关联,确定piRhsa-2700592是否具有作为房颤生物标志物的潜力。方法纳入127名非瓣膜性房颤患者,检测血浆piR-hsa-2700592相对表达水平,运用Cox比例风险回归分析外周血piR-hs...
关键词：心房颤动 CHA_(2)DS_(2)-VASc评分 PIRNA 预后 
意大利蜜蜂piR-ame-1128833的靶mRNA和功能分析
《昆虫学报》2025年第1期49-60,共12页张艺琼 李琪明 董舒楠 王宁 康婧 宓诗雨 吴鹰 蒋海宾 陈大福 郭睿 
国家自然科学基金面上项目(32372943,32172792);国家现代农业产业技术体系专项资金(CARS-44-KXJ7);福建省自然科学基金面上项目(2022J01133);福建农林大学硕士生导师团队项目(郭睿);福建农林大学科技创新专项基金(KFb22060XA);福建省大学生创新创业训练计划项目(S202310389082,202310389029)。
【目的】本研究旨在揭示意大利蜜蜂Apis mellifera ligustica成年工蜂中肠中piR-ame-1128833的调控网络和功能,为探明其作用机制提供基础。【方法】通过stem-loop RT-PCR和Sanger测序验证piR-ame-1128833在意大利蜜蜂6日龄工蜂成虫中肠...
关键词：意大利蜜蜂 PIRNA piR-ame-1128833 中肠 卵巢 精巢 靶基因 
Functions and applications of RNA interference and small regulatory RNAs被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期119-130,共12页Xuezhu Feng Shouhong Guang 
supported by the grants from the National Key R&D Program of China(Nos.2022YFA1302700 and 2019YFA0802600);the National Natural Science Foundation of China(Nos.32230016,32270583,32070619,2023M733425 and 32300438);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB39010600);the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(No.QYPY20230021);the Fundamental Research Funds for the Central Universities.
Small regulatory RNAs play a variety of crucial roles in eukaryotes,influencing gene regulation,developmental timing,antiviral defense,and genome integrity via a process termed RNA interference(RNAi).This process invo...
关键词：RNAI SIRNA MICRORNA PIRNA 
Advances in PIWI-piRNA function in female reproduction in mammals被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期148-156,共9页Xiaolong Lv Hongdao Zhang Ligang Wu 
supported by the grants from the National Key R&D Program of China(Nos.2022YFA1303301 and 2021YFA1100201);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0570000);the National Natural Science Foundation of China(Nos.31970607 and 31470781 to L.W.,No.32200696 to H.Z.);the China Postdoctoral Science Foundation(No.2021M700146 to H.Z.);the Heye Scholarship(to X.L.).
PIWI-interacting RNAs(piRNAs),which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes(piRISCs)in germline cells,are responsible for maintaining genomic integrity and reproductive f...
关键词：PIRNA PIWI TRANSPOSON OOCYTES FERTILITY 
piRNA及其生成相关基因在睾丸发育过程中的表达特征分析
《四川农业大学学报》2024年第6期1371-1380,共10页雷宇航 赵梦颖 王恺 周泰增 何晓菲 沈林園 朱砺 甘麦邻 
国家自然科学基金(32302689);四川省科技计划项目(24NSFSC1176、2021YFYZ0007、2021YFYZ0030);中国博士后科学基金(BX20230250、2023M732509);国家生猪产业技术体系(CARS-35)。
【目的】以不同发育时间点ICR小鼠为研究对象,旨在探究piRNA及其相关基因在小鼠睾丸中的表达规律,并为研究piRNA在睾丸发育和精子生成的相关调控机制提供理论依据。【方法】通过HE染色、qRT-PCR等技术手段,分析不同发育日龄小鼠睾丸组...
关键词：PIRNA 睾丸发育 精子生成 
Pathogenic TDRD12 variants cause defective piRNA pathway and male infertility in humans and mice
《Journal of Genetics and Genomics》2024年第11期1322-1326,共5页Ziyou Bao Yan Wang Renxue Wang Fan Dong Tongtong Li Wai-Yee Chan Zi-Jiang Chen Gang Lu Hongbin Liu Xiangfeng Chen 
supported by the National Key R&D Program of China(2023YFC2705503);Major Innovation Projects in Shandong Province(2021ZDSYS16);the National Natural Science Foundation of China(82071699 and 82371619);CAMS Innovation Fund for Medical Sciences(2021-I2M-5-001);the Basic Science Center Program of NSFC(31988101);Science Foundation for Distinguished Young Scholars of Shandong(ZR2021JQ27);Taishan Scholars Program for Young Experts of Shandong Province(tsqn202103192)。
Non-obstructive azoospermia(NOA),the lack of sperm in the ejaculate due to failure of spermatogenesis,can result from a variety of diverse factors,with genetic factors accounting for~30%of NOA cases,including chromoso...
关键词：VARIANTS TDR 
PiRNA-001184沉默对多发性骨髓瘤中CTGF、CDKN2A基因甲基化调控的研究
《中文科技期刊数据库（全文版）医药卫生》2024年第11期098-103,共6页王婷 贾国荣 
内蒙古自治区高等学校科学研究项目(NJZY21075)。
研究piRNA-001184沉默对人骨髓瘤细胞系(RPMI8226)中CTGF和CDKN2A基因启动子区甲基化状态的影响。方法 采用qRT-PCR方法对比正常人骨髓间干细胞与RPMI8226中piRNA-001184的表达水平;转染piRNA-001184特异性抑制物至RPMI8226,下调piRNA-0...
关键词：多发性骨髓瘤 pi-RNA DNA甲基化 
piRNA-DQ723301通过靶向调控Smad2对非酒精性脂肪肝小鼠肝星状细胞活化及功能的影响
《现代消化及介入诊疗》2024年第10期1186-1192,共7页杨雷雷 李昌平 刘超 宦徽 李沁鸿 
西藏自治区自然科学基金项目(XZ202001ZR0073G)。
目的非酒精性脂肪性肝病(NAFLD)目前已逐渐成为威胁人类生活健康的最常见的肝病之一,然而其发病机制尚未完全阐释清楚,近期有研究表明在非酒精性脂肪肝病存在异常表达的piRNAs,其中piRNA-DQ723301可能通过靶向调控Smad2参与非酒精性脂...
关键词：piRNA-DQ723301 非酒精性脂肪肝病 SMAD2 肝星状细胞 
Hotspots and research trends of Piwi-interacting RNAs from 2006 to 2023 based on bibliometric analysis
《Medical Data Mining》2024年第3期33-45,共13页Lu Shen Zhe-Zhong Zhang Shi-Liang Chen Ting-Yu Weng 
This study was funded by grants from the Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2023ZL056);the Foundation Project of Zhejiang Chinese Medical University(2022JKJNTZ16).
Background:Piwi-interacting RNAs(piRNAs)are a type of non-coding RNAs,initially identified in germ cells in 2006,known to bind to the Piwi family proteins.Accumulating studies indicate their importance in genome stabi...
关键词：PIRNA research trends bibliometric analysis VOSviewer CITESPACE 
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