Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer  

作　　者：JINGDAN QUAN ZIXIN WAN WEI WU XINYUAN CAO JIAYUAN QIU XIAOYE LIU ZHIWEI ZHANG 

机构地区：[1]Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province,Cancer Research Institute of Hengyang Medical College,University of South China,Hengyang,421001,China [2]Hengyang Medical College,University of South China,Hengyang,421001,China

出　　处：《Oncology Research》2025年第5期1069-1089,共21页肿瘤学研究(英文)

基　　金：funded by the National Key Research and Development Project,grant number 2021YFE0192100;Natural Science Foundation of Hunan Province,grant numbers 2021JJ30694,2023JJ30529;Innovation and Entrepreneurship Training Program for College Students in Hunan Province,grant number S202210555254;Key Projects of Hunan Provincial Education Department,grant number 21A0285;Natural Science Foundation of Hunan Provincial and Municipal Co-Funding,grant number 2022JJ50029;Key Projects of Shaoyang Science and Technology Bureau,grant number 2021GZ031;Innovation and Entrepreneurship Training Program for College Students of the University of South China,grant numbers D202405212006326156,D202405210948392932,D202405211329047648,D202405221955420827.

摘　　要：One of the most prevalent malignant tumors worldwide,stomach cancer still has a high incidence and fatality rate in China,and the number of young people developing early-onset gastric cancer is steadily increasing.The 5-year survival rate of stomach cancer is typically 30%–35%,the prognosis is bad,the patients’quality of life is low,and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery,chemotherapy,and other medicines.We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate,extend patient survival,and improve patient quality of life.The initial diagnosis of gastric cancer primarily depends on gastroscopy and biopsy,and invasive procedures cause significant discomfort to patients.Similar to this,treating advanced and metastatic stomach cancer is a pressing issue that requires attention.More and more immune checkpoint molecules have been discovered,and corresponding inhibitors are gradually being applied to clinical diagnosis and treatment.Recently,some non-coding RNAs have begun to be used as new targets for the treatment of gastric cancer.Some non-coding RNAs are highly present in the serum or urine of gastric cancer patients and can be used as diagnostic markers or prognostic indicators.Many clinical trials targeting non-coding RNAs have also shown good therapeutic effects.In general,targeting non-coding RNAs has shown good therapeutic effects.The biomarkers for gastric cancer detection and treatment are reviewed in this article,focusing on the new non-coding RNAs used in diagnosis,prognosis,and treatment.Patients with stomach cancer should have access to more precise and efficient diagnosis and treatment choices as a result of ongoing technological advancements and thorough research.

关 键 词：Gastric cancer Biomarkers Immune checkpoint molecules Diagnosis MicroRNA CircRNA LncRNA PIRNA 

分 类 号：R735.2[医药卫生—肿瘤]