Advances in PIWI-piRNA function in female reproduction in mammals  

作　　者：Xiaolong Lv Hongdao Zhang Ligang Wu 

机构地区：[1]Key Laboratory of RNA Science and Engineering,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第1期148-156,共9页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the National Key R&D Program of China(Nos.2022YFA1303301 and 2021YFA1100201);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0570000);the National Natural Science Foundation of China(Nos.31970607 and 31470781 to L.W.,No.32200696 to H.Z.);the China Postdoctoral Science Foundation(No.2021M700146 to H.Z.);the Heye Scholarship(to X.L.).

摘　　要：PIWI-interacting RNAs(piRNAs),which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes(piRISCs)in germline cells,are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes.Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation.In particular,studies of piRNA expression dynamics,functional redundancies,and compositional variations across mammal species have advanced our understanding of piRNA functions in male and,especially,female reproduction.These findings further support the use of hamsters as a more representative model of piRNA biology in mammals.In addition to discussing these new perspectives,the current review also covers emerging directions for piRNA research,its implications for female fertility,and our fundamental understanding of reproductive mechanisms.

关 键 词：PIRNA PIWI TRANSPOSON OOCYTES FERTILITY 

分 类 号：Q75[生物学—分子生物学]