Construction of Nanocarriers Based on Endogenous Cell Membrane and Their Application in Nanomedicine  

作　　者：Yingshu Guo Wenxin Li Shiwei Liu Dan Jing Yifan Wang Qingfang Feng Kaixiang Zhang Jing-Juan Xu 

机构地区：[1]Shandong Provincial Key Laboratory of Molecular Engineering,School of Chemistry and Chemical Engineering,Qilu University of Technology(Shandong Academyof Sciences),Jinan,Shandong 250353,China [2]School of Chemistry and Chemical Engineering,Linyi University,Linyi,Shandong 276005,China [3]State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Centre of Chemistry for Life Sciences,Nanjing University,163Xianlin Road,Nanjing,Jiangsu 210023,China [4]School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou,Henan 450001,China

出　　处：《Chinese Journal of Chemistry》2022年第13期1623-1640,共18页中国化学（英文版）

基　　金：This work was supported by the Development Plan of Youth Innovation Team in Colleges and Universities of Shandong Province(2020KJC003).

摘　　要：Inspired by the adaptation of cells to the surrounding environment,the combination of cell membrane and nanomaterials has gradually become a new type of biomimetic nanocomposite.The construction of endogenous membrane biomimetic nanocarriers(EMBNs)not only retains the structure of membrane surface protein,but also has the properties of nanoparticles(NPs),also provides the ability of natural interaction between nanomaterials and organisms,thus overcoming the severe challenges faced by traditional nanodelivery systems in clinical application.In this paper,the construction methods of EMBNs are reviewed,focusing on a simple method to prepare membrane proteins.Secondly,EMBNs were classified according a variety of cell membranes.Finally,the unique advantages of EMBNs in nanomedicine are introduced,including improving biocompatibility,homologous targeting ability,prolonging blood circulation time and immune escape abilty.In nanomedicine,such as targeted delivery,phototherapy,immunotherapy and tumor imaging,multifaceted biological interfaces through membrane masking provide a new approach for the development of multifunctional NPs.

关 键 词：Biomimeticnanocomposite Membranes NANOMEDICINE Antitumoragents DRUGDELIVERY 

分 类 号：TB383[一般工业技术—材料科学与工程]