HOTSPOT

作品数：188被引量：280H指数：8
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Oncogenic activation of PIK3CA in cancers:Emerging targeted therapies in precision oncology
《Genes & Diseases》2025年第2期143-153,共11页Yuxiang Wang Valery Rozen Yiqing Zhao Zhenghe Wang 
supported by the National Institutes of Health (USA)grantsSR01CA196643,R01CA264320,R01CA260629,P50CA150964,and P30CA043703 to Zhenghe Wang.
Phosphoinositide 3-kinases(PI3Ks)are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit.The PlIK3CA gene,which encodes the p110a,is the most frequently mutated oncogene in cancer.Oncogeni...
关键词：Hotspot mutation Isoform/mutant-specific inhibitors Metabolism PIK3CA Tumor microenvironment 
Research hotspot and trend of plant water use in karst: Based on a bibliometric analysis from 1984 to 2022
《China Geology》2025年第1期214-229,共16页De-gen Zhu Jing Ning Hui Yang Jun-bing Pu Jian-hua Cao Meng-xia Zhou Mitja Prelovsek Natasa Ravbar 
This work was supported by the National Key Research and Development Program of China(2021YFE0107100);Guangxi Key Research and Development Program(GuikeAB22035004);Guangxi Science and Technology Base and Talent Special Project(Guike AD20297090).
Research on the ecohydrological processes of terrestrial plants is a frontier field comprising ecology,hydrology and global change research,yielding the key theoretical foundations of ecohydrology.In karst areas,due t...
关键词：Terrestrial plants Plant water use Karst area Climate change ECOHYDROLOGY BIBLIOMETRICS Ecological restoration Sustainable development Environmental restoration engineering Web of Science 
Spatio-temporal correlation analysis of urbanization and ecosystem service based on grid analysis:A case study of Taixin Integrated Economic Zone,Shanxi,China
《Ecological Economy》2025年第1期2-24,共23页LIU Meng LI Shao-kun WANG Shuang LI Xiao-jing 
supported by the Natural Science Foundation of Shanxi Province(Grant No.20210302124437);the Graduate Student Research and Innovation Project of Shanxi Province(Grant No.2023KY551).
In this paper,the Taixin Integrated Economic Zone in Shanxi Province is taken as the research object,and the coupling coordination degree model and bivariate spatial autocorrelation model are used to judge the couplin...
关键词：URBANIZATION ecosystem service coupling coordination degree model bivariate spatial autocorrelation model hotspot analysis 
Mitigating Hotspot Problem Using Northern Goshawk Optimization Based Energy Aware Multi-Hop Communication for Wireless Sensor Networks
《China Communications》2025年第2期283-298,共16页S.Leones Sherwin Vimalraj J.Lydia 
Wireless Sensor Network(WSN)comprises a set of interconnected,compact,autonomous,and resource-constrained sensor nodes that are wirelessly linked to monitor and gather data from the physical environment.WSNs are commo...
关键词：CLUSTERING energy efficiency metaheuristics multihop communication network lifetime wireless sensor networks 
The Abundance of the Remaining Mammalian Fauna and the Impacts of Hunting in a Biodiversity Hotspot’s Hotspot in the Atlantic Forest of North-Eastern Brazil
《Open Journal of Ecology》2025年第1期65-91,共27页Éverton Renan de Andrade Melo José Ramon Gadelha Leandro Ricardo Rodrigues de Lucena Antonio Rossano Mendes Pontes 
Although hunting in the north-eastern Atlantic forest of Brazil began more than 500 years ago, no study to date has evaluated its impacts on the region’s mammalian fauna. For one year we carried out diurnal and noctu...
关键词：Atlantic Forest MAMMALS ABUNDANCE Human Impact Extinction 
Visual Analysis of Domestic and International Social Practice Evaluation Systems Based on CiteSpace
《Journal of Contemporary Educational Research》2025年第1期241-254,共14页Huijun Li Yuxing Xie Chuchu Zhang Guijuan He 
supported by the Zhejiang Provincial Department of Education’s General Scientific Research Project(Project No.2023-007);the Zhejiang Provincial Graduate Education Association(Project No.2023-007).
The evaluation of social practice outcomes is a critical component of the social practice mechanisms in colleges and universities,serving as a core index to assess the effectiveness of practice activities and the qual...
关键词：Social practice evaluation system Colleges and universities Practice education Knowledge graph HOTSPOT 
Characteristic spatial and frequency distribution of mutations in SCN1A
《Acta Epileptologica》2024年第4期327-335,共9页Mengwen Zhang Jing Guo Bin Li Kang Liu Jiayuan Zhao Jiayuan Zhang Xuqing Lin Bin Tang Jie Wang Weiping Liao Na He 
funded by Research Foundation of China Association Against Epilepsy(CU-2024-042);Medical Scientifc Research Foundation of Guangdong Province(A2024536);the National Natural Science Foundation of China(Grant No.82071548,Grant No.82301639 and Grant No.82201609);Guangzhou Medical University Student Innovation Ability Promoting Program(Grant No.2022A045 and Grant No.02-408-240603131135).
Background SCN1A is the most well-recognized and commonly mutated gene related to epilepsy.This study analyzed the characteristic spatial and frequency distributions of SCN1A mutations,aiming to provide important insi...
关键词：Epilepsy SCN1A CpG dinucleotides Mutation hotspot Spatial and frequency distribution 
Pediatric UTI research: trends, collaborations, and hotspot topics - a bibliometric analysis
《Life Research》2024年第4期9-16,共8页Bitesh Kumar Anjan Kumar Dhua Prabudh Goel Devendra Kumar Yadav Vishesh Jain Divya Jain 
Background:Urinary tract infection(UTI)is a prevalent bacterial infection affecting adults and pediatric populations,with distinct patterns observed in infants.This bibliometric analysis aims to provide a comprehensiv...
关键词：BIBLIOMETRY PEDIATRIC urinary tract infection vesicoureteric reflux 
Effects of upper mantle wind on mantle plume morphology and hotspot track:Numerical modeling
《Science China Earth Sciences》2024年第12期3881-3899,共19页Jie XIN Huai ZHANG Yaolin SHI Felipe ORELLANA-ROVIROSA 
supported by the National Key Scientific and Technological Infrastructure project“Earth System Science Numerical Simulator Facility”(EarthLab);supported by the National Natural Science Foundation of China(Grant Nos.U2239205,41725017)。
A mantle thermal plume may be tilted,deflected,or even split-up by mantle lateral flows(mantle wind)during its ascent,which in turn changes the spatial distribution of various geological-magmatic responses,such as mag...
关键词：Hotspot track Mantle plume Upper mantle wind Absolute plate motion Plume-derived magmatism Numerical modeling 
CHART:Intelligent Crime Hotspot Detection and Real-Time Tracking Using Machine Learning
《Computers, Materials & Continua》2024年第12期4171-4194,共24页Rashid Ahmad Asif Nawaz Ghulam Mustafa Tariq Ali Mehdi Tlija Mohammed AEl-Meligy Zohair Ahmed 
appreciation to King Saud University for funding this work through Researchers Supporting Project number(RSPD2025R685),King Saud University,Riyadh,Saudi Arabia.
Crime hotspot detection is essential for law enforcement agencies to allocate resources effectively,predict potential criminal activities,and ensure public safety.Traditional methods of crime analysis often rely on ma...
关键词：Crime hotspot heat map kernel density estimation(KDE) support vector machine(SVM) 
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