An updated study of traditional medicines to the era of 1,3,4 oxadiazole derivatives for malaria treatment  

作　　者：Davinder Kumar Harsh Kumar Aakash Deep Rakesh Kumar Marwaha 

机构地区：[1]Department of Pharmaceutical Sciences,Maharishi Dayanand University,Rohtak 124001,Haryana,India [2]Department of Pharmaceutical Sciences,Chaudhary Bansi Lal University,Bhiwani 127021,Haryana,India.

出　　处：《Traditional Medicine Research》2023年第1期36-42,共7页TMR传统医学研究

摘　　要：Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.

关 键 词：ANTIMALARIAL Plasmodium falciparum 1 3 4 oxadiazoles traditional medicines 

分 类 号：TQ460.1[化学工程—制药化工]