COUMARIN

作品数：162被引量：377H指数：7
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Coumarin Glycosides Reverse Enterococci-Facilitated Enteric Infections
《Research》2025年第1期121-134,共14页Wenjiao Xu Guixin Yuan Yuwen Fang Xiaojia Liu Xiaowei Ma Kui Zhu 
supported by the National Key Research and Development Program of China(2022YFD1801600);National Natural Science Foundation of China(32230106).
Commensal enterococci with pathogenic potential often facilitate the growth of diverse pathogens,thereby exacerbating infections.However,there are few effective therapeutic strategies to prevent and intervene in enter...
关键词：polymicrobial infections coumarin glycosides dietary coumarin g iron limitation ENTEROCOCCI enteric infections commensal enterococci glucosidases 
A Dibenzo-18-crown-6-based Symmetric Dual-coumarin Lead Ion Fluorescent Probe and Its Imaging in Living Cells
《Chemical Research in Chinese Universities》2025年第1期79-85,共7页LIU Xiaolei GONG Chongzhen PENG Xiujing SUN Guoxin YAO Wei CHU Yongjie ZHANG Tianyon 
supported by the Sub-project of the National Key R&D Project of China(No.2022YFC3902701-2);the Opened Foundation of the Key Laboratory of Molecular and Nano Probes,Ministry of Education,China(No.2020KLMNP03);the Science and Technology Program of University of Jinan,China(No.XKY2066).
Herein,a turn-on fluorescent probe for the detection of lead ions was developed using 7-diethylaminocoumarin as the fluorophore and dibenzo-18-crown-6 as the recognition unit.The response performance to lead ions was ...
关键词：COUMARIN DIBENZO-18-CROWN-6 Fluorescent probe Pb^(2+) BIOIMAGING 
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration
《Acta Pharmacologica Sinica》2025年第1期52-65,共14页Jia-qi He Ruo-lan Yuan Yu-tong Jiang Ye Peng Jun-rui Ye Sha-sha Wang Li-qing Li Yuan Ruan Pei-yi Li Xu Yan Wen-bin He Gang Li Shi-feng Chu Zhao Zhang Nai-hong Chen 
This work was supported by the National Key R&D Program of China(2022YFC3500300);National Natural Science Foundation of China(U2202214,82074044,82374060,82130109,U21A20410);the CAMSInnovationFund for Medical Sciences(CIFMS)(2021-I2M-1-020).
Esculetin(ESC)is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities.Our previous studies demonstrate that CKLF1 is a potential anti-stroke ta...
关键词：ischemic stroke ESCULETIN COUMARIN neutrophil infiltration CKLF1 CCR5 
(+)/(-)-Gerbeloid A,a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides:Structural elucidation,semi-synthesis,and lipid-lowering activity
《Acta Pharmaceutica Sinica B》2024年第6期2657-2668,共12页Chenxu Zhao Jingrong Li Yue Hu Lingyu Li Meng Yu Yunfeng Huang Tao Zhang Hai Shang Zhongmei Zou 
support from the Natural Sciences Foundation of China(82374035);the CAMS Innovation Fund for Medical Sciences(CIFMS,2022-I2M-1-017,China).
A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.2.2.0^(3,8)]decene...
关键词：Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis Lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model 
The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract
《Journal of Future Foods》2024年第2期167-172,共6页Xuting Hao Ziheng Jin Ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang 
Research on Precision Nutrition and Health Food;Department of Science and Technology of Henan Province(CXJD2021006);Science and Technology Development Program of Henan Province(222102310481;202102110136);Key University Science Research Project of Henan Province(20A360001).
Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as qu...
关键词：Cinnamomi Cortex CINNAMALDEHYDE COUMARIN Hypoglycemic effect 
Precision regulation of plant aromatic amino acid homeostasis
《Science China(Life Sciences)》2024年第6期1316-1317,共2页Jie Luo 
The aromatic amino acids(AAAs)phenylalanine(Phe),tyrosine(Tyr),and tryptophan(Trp)are not only building blocks of proteins,but also precursors of numerous primary and specialized metabolites(Schenck and Maeda,2018).Fo...
关键词：AROMATIC instance COUMARIN 
Recent advances in the biosynthesis of coumarin and its derivatives
《Green Chemical Engineering》2024年第2期150-154,共5页Yusong Zou Yuxi Teng Joy Li Yajun Yan 
supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM128620;the support from the College of Engineering,The University of Georgia,Athens
Coumarin and its derivatives,presenting in many organisms(plants,fungi,and bacteria),are critical metabolites composed of fused benzene andα-pyrone rings.With unique biological and chemical properties,coumarin deriva...
关键词：Coumarin derivatives Biosynthetic pathways BIOTRANSFORMATION Metabolic engineering 
Coumarin and eugenol ameliorate LPS-induced inflammation in RAW 264.7 cells via modulating the NLRP3 inflammasome pathway
《Asian Pacific Journal of Tropical Biomedicine》2024年第1期40-46,共7页Jyotsana Bakshi Somnath Singh KP Mishra 
supported by the Defence Institute of Physiology and Allied Sciences.
Objective:To investigate the underlying mechanism of anti-inflammatory action of coumarin and eugenol in lipopolysaccharide(LPS)-stimulated RAW 264.7 cells.Methods:RAW 264.7 cells were treated with 2.5μg/mL of LPS,50...
关键词：INFLAMMATION CYTOKINES COUMARIN EUGENOL NLRP3 LPS 
Advances in Phytochemistry and Modern Pharmacology of Saposhnikovia Divaricata(Turcz.)Schischk被引量：2
《Chinese Journal of Integrative Medicine》2023年第11期1033-1044,共12页GAO Jun-wen ZHAN Yang WANG Yun-he ZHAO Shu-jie HAN Zhong-ming 
Supported by Jilin Scientific and Technology Development Program(No.20210204011YY)。
Saposhnikovia divaricata(Turcz.)Schischk(S.divaricata,Fangfeng)is a herb in the Apiaceae family,and its root has been used since the Western Han Dynasty(202 B.C.).Chromones and coumarins are the pharmacologically acti...
关键词：COUMARIN SYNERGISTIC priori 
Recent advances in the synthesis and applications of furocoumarin derivatives
《Chinese Chemical Letters》2023年第9期119-133,共15页Chaoyue Chen Zheng-Bin Tang Zhichang Liu 
financial support from the National Natural Science Foundation of China(Nos.21971211 and 22171232);the Natural Science Foundation of Zhejiang Province(No.2022XHSJJ007);the Qiantang River Talent Foundation(No.QJD1902029);Westlake University;supported by Instrumentation and Service Centers for Molecular Science and for Physical Science(ISCMS and ISCPS);by the Mass Spectrometry&Metabolomics Core Facility at the Center for Biomedical Research Core Facilities and Westlake University HPC Center。
Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological ...
关键词：FUROCOUMARIN COUMARIN FURAN SYNTHESIS Pharmaceutical activity Applications 
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