Recent advances in the synthesis and applications of furocoumarin derivatives  

作　　者：Chaoyue Chen Zheng-Bin Tang Zhichang Liu 

机构地区：[1]School of Chemistry and Chemical Engineering,Jiangsu University of Technology,Changzhou 213001,China [2]Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province,Department of Chemistry,School of Science and Research Center for Industries of the Future,Westlake University,and Westlake Institute for Advanced Study,Hangzhou 310030,China

出　　处：《Chinese Chemical Letters》2023年第9期119-133,共15页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Nos.21971211 and 22171232);the Natural Science Foundation of Zhejiang Province(No.2022XHSJJ007);the Qiantang River Talent Foundation(No.QJD1902029);Westlake University;supported by Instrumentation and Service Centers for Molecular Science and for Physical Science(ISCMS and ISCPS);by the Mass Spectrometry&Metabolomics Core Facility at the Center for Biomedical Research Core Facilities and Westlake University HPC Center。

摘　　要：Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties,including cytotoxicity,photosensitivity,insecticidal,antibacterial,and antifungal activity,among others.The elegant linear/angular tricyclic skeleton and superior pharmacological properties,make them ideal for building and developing advanced biological scaffolds for biomedical applications.As a result,the family of furocoumarins has been the focus of intensive research,and lots of encouraging progress have been achieved in recent years.This review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family,along with their applications in medicinal chemistry covering from 2018 to 2022.

关 键 词：FUROCOUMARIN COUMARIN FURAN SYNTHESIS Pharmaceutical activity Applications 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]