This work was supported by the National Key R&D Program of China(2022YFC3500300);National Natural Science Foundation of China(U2202214,82074044,82374060,82130109,U21A20410);the CAMSInnovationFund for Medical Sciences(CIFMS)(2021-I2M-1-020).
Esculetin(ESC)is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities.Our previous studies demonstrate that CKLF1 is a potential anti-stroke ta...