CCR5 rs1799987、MnSOD rs4880基因多态性与糖尿病肾病风险相关性的meta分析  

Meta-analysis on correlation between CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms with risk of diabetic nephropathy

作　　者：刘诗斯 张斌[1] 孙强[1] LIU Shisi;ZHANG Bin;SUN Qiang(Department of Critical Care Medicine,Affiliated Hospital of Jining Medical College,Jining,Shandong 272029,China;School of Clinical Medicine,Jining Medical College,Jining,Shandong 272029,China)

机构地区：[1]济宁医学院附属医院重症医学科,山东济宁272029 [2]济宁医学院临床医学院,山东济宁272029

出　　处：《重庆医学》2024年第20期3138-3144,3149,共8页Chongqing Medical Journal

基　　金：济宁市科技局项目(2023YXNS183)。

摘　　要：目的通过meta分析研究趋化因子受体5(CCR5)rs1799987、锰超氧化物歧化酶(MnSOD)rs4880基因多态性与糖尿病肾病(DN)的相关性。方法检索的数据库包括PubMed、Embase,检索时间从建库至2023年8月12日,检索已在国外发表的CCR5 rs1799987、MnSOD rs4880多态性与DN的研究。使用纽卡斯尔-渥太华量表(NOS)进行质量评价。采用Stata16.0软件进行统计分析,采用OR及95%CI作为效应量评价CCR5 rs1799987、MnSOD rs4880基因多态性与DN发生的关系。采用漏斗图和Egger检验评估发表偏倚。结果共纳入14篇文献进行meta分析,糖尿病肾病病例组(case)4470例,非糖尿病肾病对照组(control)4211例。CCR5 rs1799987、MnSOD rs4880基因多态性与DN存在相关性(P<0.05),亚洲人种、2型糖尿病CCR5 rs1799987、MnSOD rs4880基因多态性与DN存在相关性(P<0.05)。CCR5 rs1799987基因中突变基因型A、AA和MnSOD rs4880基因中突变基因型VV可能是DN发生的危险因素。结论CCR5 rs1799987、MnSOD rs4880基因多态性与DN存在相关性,尤其是亚洲人种、2型糖尿病患者。Objective To investigate the correlation between C-C chemokine receptor type 5(CCR5)rs1799987 and manganese superoxide dismutase(MnSOD)rs4880 gene polymorphisms with diabetic nephropathy(DN).Methods The retrieved databases included PubMed and Embase.The retrival time wasfrom the database establishemnt to 12 August 2023.The studies on the CCR5 rs1799987 and MnSOD rs4880 polymorphisms and DN published abroad were retrived.The Newcastle-Ottawa Scale(NOS)was employed for conducting the quality assessment.The statistical analysis was performed by using Stata 16.0 software,and the relationship between the CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms with DN occurrence was evaluated by using OR and 95%CI as the effect sizes.The funnel plots and Egger’s test were utilized to assess the publication bias.Results A total of 14 articles were included for conducting the meta-analysis,including 4470 cases in the DN case group and 4211 cases in the non-DN control group.The CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms had the correlaation with DN(P<0.05).The Asians,CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms of type 2 diabetes mellitus had the correlation with DN(P<0.05).The mutant genotypes A and AA in the CCR5 rs1799987 gene,as well as the VV genotype in the MnSOD rs4880 gene could be the risk factors for DN occurrence.Conclusion CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms have the correlation with DN,especially Asian and patients with type 2 diabetes mellitus.

关 键 词：趋化因子受体5 rs1799987 锰超氧化物歧化酶rs4880 糖尿病肾病 META分析 

分 类 号：R394[医药卫生—医学遗传学]