Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling  

作　　者：CHENG Yao-Jun TIAN Xin-Lei ZENG Ya-Zhi LAN Nan GUO Ling-Feng LIU Ke-Feng FANG Hui-Long FAN Hong-Ye PENG Zhong-Lu 

机构地区：[1]Key Laboratory of Universities in Hunan Province on Cardiovascular and Cerebrovascular Natural Drugs Research,Xiangnan University,Chenzhou 423000,China [2]State Key Laboratory of Natural Medicines,School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2021年第6期432-441,共10页中国天然药物（英文版）

基　　金：supported by the Key Project of Scientific Research Fund of Hunan Provincial Education Department(15A177);the Natural Science Foundation of Hunan Province(2019JJ40275).

摘　　要：Esculetin,a natural derivative from the traditional and widely-used Chinese medicinal herb Cortex Fraxini,has a variety of pharmacological effects,especially in anti-inflammation.However,it is not clear whether esculetin has a therapeutic effect on sepsis.This study aimed to investigate the anti-inflammatory and protective effects of esculetin on early sepsis.The results showed that the lung injury was significantly relieved with the treatment of esculetin,accompanied with the restrained production of inflammatory factors including IL-1β,IL-6,TNF-α,CCL2 and iNOS during the early phase of E.coli-induced sepsis.Of note,activation of NF-κB and STAT1/STAT3 signals,the main upstream signals of many inflammatory factors,were attenuated by esculetin in both lung tissues from septic mice and LPS-stimulated macrophage.These findings suggested that the protection of esculetin against early sepsis should be related to its anti-inflammatory effect,which was at least partly due to its inhibition on NF-κB and STAT1/STAT3 signaling pathway in macrophage.Thus,esculetin could serve as a potential therapeutic agent by rebalancing innate immune response in macrophage for the treatment of early sepsis.

关 键 词：ESCULETIN NF-ΚB STAT1 STAT3 Early sepsis 

分 类 号：R965[医药卫生—药理学]