Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma  

作　　者：Yueying Gao Jinyang Yu Zhi Li Kefan Liu Jiwei Pan Ya Zhang Yanlin Ma Jiwei Zhang Zhigang Liu Yongsheng Li 

机构地区：[1]Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research,Department of Reproductive Medicine,Hainan Provincial Clinical Research Center for Thalassemia,Key Laboratory of Reproductive Health Diseases Research and Translation,Ministry of Education,The First Affiliated Hospital of Hainan Medical University,College of Biomedical Information and Engineering,Hainan Medical University,Haikou,Hainan 571101,China [2]School of Interdisciplinary Medicine and Engineering,Harbin Medical University,Harbin,Heilongjiang 150081,China [3]The MOE Key Laboratory for Standardization of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [4]Affiliated Foshan Maternity&Child Healthcare Hospital,Southern Medical University,Guangzhou,Guangdong 510000,China

出　　处：《Genes & Diseases》2025年第2期48-51,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China (No.32322020,32170676,31970646,32060152);the Natural Science Foundation of Heilongjiang Province,China (Key Program,No.ZD2023C007);Heilongjiang Touyan Innovation Team Program (China);the specific research fund of The Innovation Platform for Academicians of Hainan Province,China;the project supported by Hainan Province Clinical Medical Center (China).

摘　　要：Hepatocellular carcinoma(HCC)is one of the most common tumors with high prevalence and death rate,which lacks effective targeting and immunotherapy currently.Metabolic reprogramming,which provides an inherent advantage for tumor cells to compete for nutrition,plays important roles in the development and progression of cancers.

关 键 词：METABOLISM IMMUNOTHERAPY PROGRAMMING 

分 类 号：R73[医药卫生—肿瘤]