NEUROBLASTOMA

作品数：184被引量：322H指数：9
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相关领域：医药卫生更多>>
相关作者：钟玉敏王晓霞周莺刘洲禄王鸿丽更多>>
相关机构：首都医科大学南京医科大学第二附属医院中国人民解放军总医院上海交通大学医学院附属上海儿童医学中心更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis
《Genes & Diseases》2025年第3期382-396,共15页Kai Huang Linyu Yang Yue Ma Lijian Cao Suwen Li Zhenzhen Zhao Jianwu Zhou Shan Wang 
supported in part by research grants from the Key Project of the National Key R&D Plan“Research on Prevention and Control of Major Chronic Non-Communicable Diseases”(China);the Ministry of Science and Technology of the People’s Republic of China,and the National Key R&D Program of China(No.2018YFC1313000,2018YFC1313004).
The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM)and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiti...
关键词：Bone marrow metastasis Bone metastasis IMMUNOTHERAPY Multi-omics NEUROBLASTOMA Transketolase(TKT) 
Targeting the MYCN-MDM2 pathways for cancer therapy:Are they druggable?
《Genes & Diseases》2025年第2期271-287,共17页Wei Wang Yi Du Sayantap Datta Josef F.Fowler Hannah T.Sang Najah Aibadari Wei Li Jennifer Foster Ruiwen Zhang 
supported by the National Institutes of Health (NIH)/National Cancer Institute (No.R01CA214019 to RZ);support was provided by the NCl grant R01CA240447 to WL.
Targeting oncogenes and their interactive partners is an effective approach to developing novel targeted therapies for cancer and other chronic diseases.We and others have long suggested the MDM2 oncogene being an exc...
关键词：MDM2 MYCN NEUROBLASTOMA Signaling pathway Targeted therapy 
Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci
《Chinese Journal of Cancer Research》2025年第1期1-11,共11页Wenli Zhang Jinhong Zhu Mengzhen Zhang Jiaming Chang Jiabin Liu Liping Chen Xinxin Zhang Haiyan Wu Chunlei Zhou Jing He 
supported by grants from the National Natural Science Foundation of China(No.82173593,32300473);Guangzhou Science and Technology Project(No.2025A04J4537,2025A04J4696);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220053);Postdoctoral Science Foundation of Jiangsu Province(No.2021K524C).
Objective:Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings.Previous genome-wide association studies(GWASs)have identified many loci associated with neuroblast...
关键词：GWAS POLYMORPHISM NEUROBLASTOMA SUSCEPTIBILITY polygenic risk score 
Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China
《World Journal of Stem Cells》2025年第2期42-52,共11页Zi-Yan Luo Li-Qun Fan Wen-Ling Guo Jian-Ping Yang Zhuo-Yan Li Yong-Xian Huang Hua Jiang Xiao-Hong Zhang 
Guangzhou Municipal Science and Technology Bureau,Municipal School and College Joint Funding Project,No.2024A03J1240.
BACKGROUND Despite advances in treatment,the prognosis for patients with high-risk pediatric solid tumors remains dismal.Tandem autologous stem cell transplantation(ASCT)offers promise for improving outcomes in these ...
关键词：Autologous stem cell transplantation Pediatric solid tumors NEUROBLASTOMA Survival outcomes Prognostic factors 
Biallelic inactivation of SDHA results in comorbidity of pediatric recurrent neuroblastoma and gastric stromal tumor
《Genes & Diseases》2024年第6期99-102,共4页Shen Yang Shixuan Zhang Wen Zhao Libing Fu Li Zhang Chan Hon Chui Ruolan Guo Yan Su Dayan Sun Huanmin Wang 
supported by the National Natural Science Foundation of China (No.82293660,82293665);the Consulting and Research Project of the Chinese Academy of Engineering (No.2019-XY-34).
Neuroblastoma(NB)is a common pediatric extracranial solid tumor that exhibits varied characteristics,clinical features,and prognosis.1 Totally 1%-2%of cases show familial history with genetic links like ALK,PHOX2B mut...
关键词：PEDIATRIC NEOPLASMS NEUROBLASTOMA 
Acquired RD3 loss regulates immune surveillance in high-risk and therapy defying progressive neuroblastoma
《Cancer Communications》2024年第12期1427-1430,共4页Poorvi Subramanian Sreenidhi Mohanvelu Dinesh Babu Somasundaram Sheeja Aravindan Natarajan Aravindan 
funded by Department of Defense(DoD CA-210339);Oklahoma Center for the Advancement of Science and Technology(OCAST-HR19-045);the National Institutes of Health(P20GM103639);supported by the National Cancer Institute Cancer Center Support Grant(P30CA225520);a grant from the Oklahoma Tobacco Settlement Endowment Trust(R23-03)both awarded to the OU Health Stephenson Cancer Center.
Neuroblastoma(NB)is the most common extra cranial solid tumor in children and comprises one tenth of all childhood cancer deaths.More than half of infants presented with NB,a designated“cold tumor”with low immune ce...
关键词：NEUROBLASTOMA IMMUNE tumor 
Radiomics models to predict bone marrow metastasis of neuroblastoma using CT被引量：1
《Cancer Innovation》2024年第5期71-83,共13页Xiong Chen Qinchang Chen Yuanfang Liu Ya Qiu Lin Lv Zhengtao Zhang Xuntao Yin Fangpeng Shu 
Science and Technology Projects in Guangzhou,Grant/Award Number:202201011843;National Natural Science Foundation of China,Grant/Award Numbers:82103544,82202251。
Background:Bone marrow is the leading site for metastasis from neuroblastoma and affects the prognosis of patients with neuroblastoma.However,the accurate diagnosis of bone marrow metastasis is limited by the high spa...
关键词：bone marrow metastasis machine learning NEUROBLASTOMA radiomics 
MicroRNA-32-5p inhibits metastasis by directly targeting VPS4B and increases sensitivity to dihydroartemisinin in neuroblastoma
《Science of Traditional Chinese Medicine》2024年第3期202-213,共12页Lina Chen Hui Liu Zhongyuan Zheng Shuiqing Qu Yu Zhang Shuoqiu Deng Shuo Shena Tuo Liu Yue Dai Yu Li Honghua Cui Yujie Li 
supported by the Fundamental Research Funds for the Central PublicWelfare Research Institutes(grant ZZ13-YQ-100);the NationalNatural Science Foundation of China(grants 82274181 and 82141001);Innovation Fund of China Academy of Chinese Medical Sciences(grantsCI2021A05106,CI2021A04611,andZZ16-ND-10-01);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021B015,CI2023E001TS12).
Background:Neuroblastoma(NB)is a malignant pediatric tumor requiring new therapies.Accumulating evidence has confirmed that microRNAs play critical roles in NBmetastasis.Dihydroartemisinin(DHA)is capable of inhibiting...
关键词：Neuroblastoma metastasis MiR-32-5p DIHYDROARTEMISININ Vacuolar protein sorting 4B(VPS4B) 
Interferon-gamma regulates the progression of neuroblastoma cells through interferon-regulatory factor-1
《BIOCELL》2024年第9期1343-1353,共11页JING WANG JUNFENG XU YINGRAN YANG YOUZHENG QIU SHANSHAN ZHANG NING WANG 
funded by the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities’Association(No.202101BA070001-126).
Objective:This study aimed to elucidate the influence of IFN-gamma(IFN-γ)in neuroblastoma(NB)cells and reveal its potential underlying molecular mechanism.Methods:The Cell Counting Kit-8,Transwell apparatus,and flow ...
关键词：NEUROBLASTOMA N-Myc-amplified Non-N-Myc-amplified IFN-γ IRF-1 
Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma
《Frontiers of Medicine》2024年第4期690-707,共18页Zhe Nian Dan Wang Hao Wang Wenxu Liu Zhenyi Ma Jie Yan Yanna Cao Jie Li Qiang Zhao Zhe Liu 
supported by the National Natural Science Foundation of China(Nos.81825017,81773034 to Zhe Liu,8217113342,81872350 to Zhenyi Ma);the Ministry of Science and Technology of China(No.2018YFC1313002 to Zhe Liu);the Tianjin Municipal Science and Technology Commission(No.20JCZDJC00110 to Zhe Liu);the Interdisciplinary Research Project of Hangzhou Normal University(No.2024JCXK03 to Zhe Liu);the Haihe Laboratory of Cell Ecosystem Innovation Fund(No.HH22KYZX0025 to Zhe Liu).
Neuroblastoma(NB)is one of the most common childhood malignancies.Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes.However,the molecular mechanisms trigg...
关键词：single-cell RNA sequencing METASTASIS NEUROBLASTOMA epithelial-to-mesenchymal transition 
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