Biallelic inactivation of SDHA results in comorbidity of pediatric recurrent neuroblastoma and gastric stromal tumor  

作　　者：Shen Yang Shixuan Zhang Wen Zhao Libing Fu Li Zhang Chan Hon Chui Ruolan Guo Yan Su Dayan Sun Huanmin Wang 

机构地区：[1]Department of Oncology Surgery,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [2]State Key Laboratory of Genetic Engineering,Collaborative Innovation Center for Genetics and Development,School of Life Sciences and Human Phenome Institute,Fudan University,Shanghai 200438,China [3]Hematology Oncology Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing100045,China [4]Department of Pathology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [5]Shanghai Institute of Precision Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China [6]Surgery Centre for Children,Mount Elizabeth Medical Centre,228510,Singapore [7]Beijing Key Laboratory for Genetics of Birth Defects,Beijing Pediatric Research institute,MOE Key Laboratory of Major Diseases in Children,Genetics and Birth Defects Control Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [8]Department of Neonatal Surgery,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [9]MOE Key Laboratory of Major Diseases in Children,Beijing Children's Hospital,Capital Medical University,National Centerfor Children's Health,Beijing 100045,China

出　　处：《Genes & Diseases》2024年第6期99-102,共4页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China (No.82293660,82293665);the Consulting and Research Project of the Chinese Academy of Engineering (No.2019-XY-34).

摘　　要：Neuroblastoma(NB)is a common pediatric extracranial solid tumor that exhibits varied characteristics,clinical features,and prognosis.1 Totally 1%-2%of cases show familial history with genetic links like ALK,PHOX2B mutations,and1p36or11q14-23locusdeletions.Gastrointestinal stromal tumors(GISTs)are rare mesenchymal neoplasms of the gastrointestinal tract.

关 键 词：PEDIATRIC NEOPLASMS NEUROBLASTOMA 

分 类 号：R739.41[医药卫生—肿瘤]