Serum Iron Overload Triggers the SMAD Pathway and Induces Hepcidin Expression in Hepatocytes through SMURF1  

作　　者：Taha Yazal Chia-Yang Li 

机构地区：[1]School of Medicine,College of Medicine,Kaohsiung Medical University,Kaohsiung [2]Graduate Institute of Medicine,College of Medicine,Kaohsiung Medical University,Kaohsiung [3]Department of Medical Research,Kaohsiung Medical University Hospital,Kaohsiung [4]Department of Biological Science and Technology,National Pingtung University of Science and Technology,Pingtung

出　　处：《Journal of Clinical and Translational Hepatology》2024年第9期761-762,共2页临床与转化肝病杂志（英文版）

基　　金：supported by grants from the National Science and Technology Council,Taiwan,R.O.C.(grant No.NSTC 113-2314-B-037-128 and NSTC 112-2926-I-037-501-G,);Kaohsiung Medical University(grant No.KT113P010).

摘　　要：Dear Editors,In the article“Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1”,Ning Zhang et al.studied the molecular mechanisms linking serum iron overload to hepcidin expression,emphasizing the role of SMURF1 as a pivotal regulator of the bone morphogenetic proteins(BMP)/SMAD pathway in response to holo-transferrin induction.1 This research is significant given hepcidin’s crucial role in iron homeostasis and the pathophysiology of iron overload disorders,such as hereditary hemochromatosis.

关 键 词：SERUM SMAD 

分 类 号：R575[医药卫生—消化系统]