Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review  

作　　者：Jing Ye Jian-Guo Wang Rong-Qiang Liu Qiao Shi Wei-Xing Wang 

机构地区：[1]Department of General Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China [2]Department of Pancreatic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China

出　　处：《World Journal of Gastroenterology》2025年第2期27-41,共15页世界胃肠病学杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.82170651;and the Research Support Fund of Hubei Microcirculation Society,No.HBWXH2024(1)-1.

摘　　要：Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent years.The prevalence of IPFD is relatively high and associated with factors such as obesity,age,and sex.However,the pathophysiological mechanisms underlying IPFD remain unclear,with several potential contributing factors,including oxida-tive stress,alterations in the gut microbiota,and hormonal imbalances.IPFD was found to be highly correlated with the occurrence and prognosis of exocrine pan-creatic diseases.Although imaging techniques remain the primary diagnostic approach for IPFD,an expanding array of biomarkers and clinical scoring systems have been identified for screening purposes.Currently,effective treatments for IPFD are not available;however,existing medications,such as glucagon-like peptide-1 receptor agonists,and new therapeutic approaches explored in animal models have shown considerable potential for managing this disease.This paper reviews the pathogenesis of IPFD,its association with exocrine pancreatic disea-ses,and recent advancements in its diagnosis and treatment,emphasizing the significant clinical relevance of IPFD.

关 键 词：Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease PANCREATITIS Pancreatic cancer 

分 类 号：R576[医药卫生—消化系统] R587.1[医药卫生—内科学]