A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening  

作　　者：Zinan Zhang Wenbin Cao Huanchun Xing Shuai Guo Lijuan Huang Lin Wang Xin Sui Kui Lu Yuan Luo Yongan Wang Jun Yang 

机构地区：[1]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institutes of Pharmacology and Toxicology,Beijing 100850,China [2]Tianjin University of Science and Technology,Tianjin 300222,China [3]Hebei University of Science and Technology,Shijiazhuang 050018,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第4期1827-1844,共18页药学学报（英文版）

摘　　要：In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on selective opening of the BBB.This strategy allows some simple bare nanoparticles to enter the brain when mixed with special opening material;however,the BBB still maintains the ability to completely block molecules from passing through.Based on the screening of BBB opening and matrix delivery mate-rials,we determined that phospholipase A2-catalyzed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine li-posomes can efficiently carry drugs into the brain immediately.At an effective dose,this delivery system is safe,especially with its effect on the BBB being reversible.This mix&act delivery system has a simple structure and rapid preparation,making it a strong potential candidate for drug delivery across the BBB.

关 键 词：Liposomes Phospholipase A2 PHOSPHOSERINE Blood-brainbarrier Selectively open Mix&act 

分 类 号：R943[医药卫生—药剂学]