Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair  

作　　者：Yuwei Liu Gang Wang Huitong Luo Bangjiao Zhao Muheng Liao Qiyuan Dai Maocai Li Qingtao Li Xiaodong Cao 

机构地区：[1]School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,P.R.China [2]National Engineering Research Centre for Tissue Restoration and Reconstruction,Guangzhou 510006,P.R.China [3]School of Medicine,South China University of Technology,Guangzhou 510006,P.R.China [4]Key Laboratory of Biomedical Engineering of Guangdong Province,South China University of Technology,Guangzhou 510006,P.R.China [5]Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,South China University of Technology,Guangzhou 510006,P.R.China [6]Zhongshan Institute of Modern Industrial Technology of SCUT,Zhongshan,Guangdong 528437,P.R.China

出　　处：《Regenerative Biomaterials》2023年第1期1135-1148,共14页再生生物材料（英文版）

基　　金：supported by the Fundamental Research Funds for the Central Universities(grant number 2022ZYGXZR105);the National Natural Science Foundation of China(grant numbers 52272276,52073103,52203164);the Zhongshan Innovation Project of high-end Scientific Research Institutions(grant number 2020AG020)。

摘　　要：Flexible hydrogels containing various osteogenic inorganic constituents,which can accommodate complicated shape variations,are considered as ideal grafts for craniofacial bone defect reconstruction.However,in most hybrid hydrogels,poor interaction between the polymer network and particles has detrimental effects on hydrogel rheological and structural properties,clinical manipulation and repair efficacy.In this article,we designed and prepared a series of hyaluronic acid composite hydrogel containing Cu-doped bioactive glass(CuBG)and phosphoserine(PS),in which hyaluronic acid was modified by methacrylate groups and phenylboronic acid groups to form a double crosslinked network.PS acted as an interaction bridge of CuBG particles and HAMA-PBA network to improve the mechanical properties of the composite hydrogels.The CuBG/PS hydrogels exhibited suitable rheological properties(injectable,self-healing,shape-adaptable),bone tissue integrating ability and anti-bacterial property.Meanwhile,we found that CuBG and PS have synergistic effect on improving osteogenic efficiency both in vitro and in vivo,particularly when the ratio of CuBG to PS is lower than 3(9CB/3PS).This work provided a versatile and scalable approach to enhanced the interaction within inorganic particles and polymer network in hydrogels without extra modification on components.

关 键 词：Cu-doped bioactive glass PHOSPHOSERINE dynamic hydrogel craniofacial bone defect 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]